Objective: To optimize the best extraction technology of Hanbi patch. Method: Orthogonal test was used to optimize alcohol extraction process of Aconiti Kusnezoffii Radix with the yield of total alkaloid as index;Optimize decocting technology of Paeoniae Radix Rubra and other five herbs by orthogonal design with the extraction amount of paeoniflorin as index. Result: The optimum extraction technology was as follows:Aconiti Kusnezoffii Radix was refluxed with 6 times amount of 70% ethanol for two times by 2 h per time. Paeoniae Radix Rubra and other herbs was added 8 times amount of water for three times with 1 h each time. Conclusion: The optimized extraction process is reasonable

feasible and provide scientific basis for the production.