Effect of Hance on HBsAg and HBeAg in the HepG2.2.15 Cells

CHEN Xiao-bai; WANG Xiao-ping; WEI Min

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Effect of Hance on HBsAg and HBeAg in the HepG2.2.15 Cells

更新时间：2024-01-04

- Effect of Hance on HBsAg and HBeAg in the HepG2.2.15 Cells
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 22, Pages: 184-186(2011)
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- Published：2011
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CHEN Xiao-bai, WANG Xiao-ping, WEI Min. Effect of Hance on HBsAg and HBeAg in the HepG2.2.15 Cells[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(22): 184-186.
DOI：

CHEN Xiao-bai, WANG Xiao-ping, WEI Min. Effect of Hance on HBsAg and HBeAg in the HepG2.2.15 Cells[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(22): 184-186. DOI：

摘要

目的: 观察毛鸡骨草体外抗乙型肝炎病毒(HBV)的作用。方法: 采用MTT法检测毛鸡骨草对HepG2.2.15细胞的半数毒性浓度(TC50)和最大无毒浓度(TC0)

采用酶联免疫吸附实验(ELISA)法测定0的5个不同浓度的毛鸡骨草醇提液对HepG2.2.15细胞株表达的乙型肝炎表面抗原(HBsAg)和乙型肝炎E抗原(HBeAg)的影响。结果: 毛鸡骨草醇提取液可有效地抑制细胞HBsAg和HBeAg的分泌;在质量浓度为4 g·L-1作用144 h对HBsAg

HBeAg抑制作用最为明显

抑制率分别为33.1%

40.1%。结论: 毛鸡骨草在体外有一定的抗HBV作用。

Abstract

Objective: To observe the inhibitive effect of Abrus mollis Hance on HBV. Method: The TC50 and TC0 of A. mollis to the HepG2.2.15 ceils were determined by MTT assay. The effect of 0 five different concentrations of alcohol extract of A. mollis on HBsAg and HBeAg in the HepG2.2.15 cells was determined by ELISA. Result: A. mollis had a inhibiting effect on the HBsAg and HBeAg with maximum inhibition ratio adding up to 33.1% and 40.1%

respectively

in which the affective time was 144 h and the density was 4 g·L-1. Conclusion: A. mollis can significantly inhibit HBV in vitro.

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