Preparation and Release of  Saponins Enteric Microcapsules

LU Shi-hua; LIU Hua-gang; LAI Ling; QIN Yan-e; WEN Li; Chen Ming; LIU Guan-ping

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Preparation and Release of Saponins Enteric Microcapsules

更新时间：2024-01-04

- Preparation and Release of Saponins Enteric Microcapsules
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 14, Pages: 11-14(2011)
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- Published：2011
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LU Shi-hua, LIU Hua-gang, LAI Ling, et al. Preparation and Release of Saponins Enteric Microcapsules[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(14): 11-14.
DOI：

LU Shi-hua, LIU Hua-gang, LAI Ling, et al. Preparation and Release of Saponins Enteric Microcapsules[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(14): 11-14. DOI：

摘要

目的: 探讨三七总皂苷(PNS)肠溶微囊的制备方法

并对其进行体外释放度研究。方法 :以聚丙烯酸树脂Ⅱ为囊材

采用溶剂-非溶剂法制备PNS肠溶微囊

并考察其包封率、载药量及其体外释放性能。结果 : 3批PNS肠溶微囊的包封率分别为90.85%

90.15%

89.06%;载药量分别为26.05%

25.04%

25.16%;R1

Rg1

Rb1在人工胃液中释放量＜10%

人工肠液中45 min累积释放率分别达到86.08%

88.76%

84.98%。结论 : 溶剂-非溶剂法制备PNS肠溶微囊方法简单

体外释放符合药典对肠溶制剂的要求。

Abstract

Objective: To study the preparation method of PNS enteric microcapsules and to investigate the release properties in vitro. Method : The solvent-non-solvent extraction was used to prepare enteric microcapsule of PNS with the polyacrylic acid resin II as the pouch material. The encapsulation efficacy and loading efficiency as well as the properties in vitro release of PNS enteric microcapsules were investigated. Result : Encapsulation efficiency was 90.85%

90.15%

and 89.06%

loading efficiency was 26.05%

25.04%

and 25.16% respectively. The release of R1

Rg1 and Rb1 was less than 10% in the artificial gastric juices

and up to 86.08%

88.76%

and 84.98% in the artificial intestinal juices after 45 min. Conclusion : The microcapsules meet the requirements of pharmacopoeia in vitro release.

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