Protective Effects of Panaxynol on Nerve Cells under Oxygen and Glucose Deprivation
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Protective Effects of Panaxynol on Nerve Cells under Oxygen and Glucose Deprivation
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 16, Pages: 180-183(2011)
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Published:2011
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DUAN Xian-chun, XIA Lun-zhu, WANG Yong-zhong, et al. Protective Effects of Panaxynol on Nerve Cells under Oxygen and Glucose Deprivation[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(16): 180-183.
DOI:
DUAN Xian-chun, XIA Lun-zhu, WANG Yong-zhong, et al. Protective Effects of Panaxynol on Nerve Cells under Oxygen and Glucose Deprivation[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(16): 180-183.DOI:
Protective Effects of Panaxynol on Nerve Cells under Oxygen and Glucose Deprivation
Objective: To study the protective effects of panaxynol against nerve cells injury induced by oxygen glucose deprivation (OGD). Method: Cultured PC12 cells
treated with OGD
panaxynol (10
20 mg·L-1) and nimodipine (100 μmol·L-1)
were divided into control group
OGD group
panaxynol group and nimodipine group. Cell morphology was observed by fluorescence microscopy and neuronal apoptosis was detected by Hoechst/PI double-dyed flow cytometry
through to determine the release of LDH and cell i
the neuroprotective effect of panaxynol was observed. Result: Panaxynol could reduce the LDH release of PC12 cell injury induced by OGD (P<0.05
0.01)
restrain the production of Ca2+(P<0.05
0.01)
decrease neuron apoptosis and necrosis significantly (P<0.05
0.01). Conclusion: Panaxynol can reduce nerve cells injury induced by OGD
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