Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 19, Pages: 261-263(2011)
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Published:2011
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LI Dai-xiao, LV Ying-chao, ZHANG Xiao-feng. Mechanism of Shuweifang Cure Functional Dyspepsia[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(19): 261-263.
DOI:
LI Dai-xiao, LV Ying-chao, ZHANG Xiao-feng. Mechanism of Shuweifang Cure Functional Dyspepsia[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(19): 261-263.DOI:
Objective: To observe the changes of small intestines movement and motilin
substance P(SP) levels of rats with functional dyspepsia
to discuss the mechanism. Method: The animal model of functional dyspepsia was established by irregular feeding and stimulating tails of the rats. Forty-eight Wistar rats were randomized into control group
madinglin group
high
middle and low dose groups of shuweifang and modle group
8 rats in each group. The content of motilin and substance P in plasma were determined by radiommunoassay. And advance rate of small intestines were observed with phenolsulfonphthalein. Result: Compared to the control group
the contents of Motilin(MTL)
SP and advance rate of small intestines in model group were obviously decreased(P<0.05)
while in the Shuweifang and Madinglin group increased significantly(P<0.05). Conclusion: Shuweifang can increase the contents of MTL and SP in the plasma of model rats and promote advance rate of small intestines which is probably one of the mechanisms in the treatment of functional dyspepsia.
Effect and Relevant Mechanism of Jichuanjian on Gastrointestinal Peristalsis in Senile Rat
Effect of Shuweitang on Expression of Interstitial Cells of Cajal and Motilin in Functional Dyspepsia Rats
Effect of Decoction of Invigorating Spleen and Regulating Qi on Gastrointestinal Motility, Motilin and Gastrin in Rats with Functional Dyspepsia
Influenction of Shuwei Decoction on Substance P and Interstitial Cells of Cajal in Functional Dyspepsia Rat
Clinical Efficacy of Xiangsha Liujunzi Tang Combined with Acupuncture Therapy in Treatment of Syndrome of Deficiency of Spleen Qi and Stomach Qi of Functional Dyspepsia
Modern Research Center for TCM,Beijing Academy of TCM, Beijing University of Chinese Medicine
Dongzhimen Hospital, Beijing University of Chinese Medicine
Beijing Key Laboratory of Syndrome and Prescription Basic Research, Key Laboratory of Syndrome and Prescription Basic Research,Ministry of Education, School of Traditional Chinese Medicine(TCM),Beijing University of Chinese Medicine