Effect of Cinnamon on Strychnos Studied by Sequential Acute Toxicity Test

ZHU Jian-wei; YAN Xue-sheng; LIU Jin

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Effect of Cinnamon on Strychnos Studied by Sequential Acute Toxicity Test

更新时间：2024-01-04

- Effect of Cinnamon on Strychnos Studied by Sequential Acute Toxicity Test
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 20, Pages: 245-247(2011)
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- Published：2011
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ZHU Jian-wei, YAN Xue-sheng, LIU Jin. Effect of Cinnamon on Strychnos Studied by Sequential Acute Toxicity Test[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(20): 245-247.
DOI：

ZHU Jian-wei, YAN Xue-sheng, LIU Jin. Effect of Cinnamon on Strychnos Studied by Sequential Acute Toxicity Test[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(20): 245-247. DOI：

摘要

目的: 研究肉桂对马钱子的减毒作用。方法: 单纯马钱子煎液、马钱子肉桂煎液(马桂煎液1 ∶5)

其中马钱子生药含量都是20%。用序贯试验测定两种马钱子制剂的LD50。比较其毒性。结果: 单纯马钱子LD50=(173.161±18.289) mg·kg-1

马桂煎液LD50=(781.345±214.744) mg·kg-1

马桂煎液从中毒至死亡时间明显延长。结论: 马钱子与肉桂合煎后毒性明显降低。

Abstract

Objective: To study the attenuated effect of cinnamon on strychnos. Method: The mice were administrated with strychnos decoction or strychnos-cinnamon decoction (strychnos ∶cinnamon=1 ∶5) intragastrically. The half lethal dose (LD50) of both decoctions were studieded and compared by the sequential acute toxicity test. Result: LD50 of the two decoction were strychnos decoction=(173.161±18.289) mg·kg-1

strychnos-cinnamon decoction=(781.345 ± 214.744) mg·kg-1. In addition

the average time from poisoning to death of the mice administrated with strychnos-cinnamon decoction was significantly longer than that of mice with strychnos deconction. Conclusion: Cinnamon can reduce the toxicity of strychnos significantly.

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