Studies on Metabolism of Radix from

ZHAO Bao-sheng; DONG Ling; LIU Yang; SHI Ren-bing; XU Tun-hai; ZHAI Hua-qiang; FANG Min; WANG Guo-peng; FU Xiao-mei

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Studies on Metabolism of Radix from

更新时间：2024-01-04

- Studies on Metabolism of Radix from
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 18, Pages: 144-148(2011)
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- Published：2011
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ZHAO Bao-sheng, DONG Ling, LIU Yang, et al. Studies on Metabolism of Radix from [J]. Chinese journal of experimental traditional medical formulae, 2011, 17(18): 144-148.
DOI：

ZHAO Bao-sheng, DONG Ling, LIU Yang, et al. Studies on Metabolism of Radix from [J]. Chinese journal of experimental traditional medical formulae, 2011, 17(18): 144-148. DOI：

摘要

目的: 研究黄芩 Scutellaria baicalensis Georgi 根中紫外可检出成分的代谢过程。方法: ①运用HPLC-DAD技术建立黄芩水提物化学成分特征谱

进行其总体化学成分的并行即时监测;②肝门静脉采血

建立黄芩水提物入血成分特征谱;③腹主动脉采血

建立黄芩水提物血中成分特征谱;④离体外翻肠囊法研究黄芩水提取物在大鼠无菌肠道的吸收

建立黄芩水提物肠吸收成分特征谱;⑤在相同色谱条件下

分析比较大鼠肝门静脉入血成分、腹主动脉血中成分及肠吸收成分的化学成分特征谱

推断黄芩水提取物中化学成分的代谢过程。结果: 分析的17种成分中

4种成分被肠道菌群代谢转化

未能吸收入血

4种成分不能被肠直接吸收

7种成分可被肠道直接吸收入血;血中出现的1种成分在黄芩水提取物中未能查见

推测其为肠代谢转化后新生的成分吸收入血。结论: 采用大鼠肝门静脉入血成分、腹主动脉血中成分及肠吸收成分(离体翻转肠囊法)的HPLC-DAD化学成分特征谱分析比较法可以判定中药整体用药时所含化学成分的代谢过程。

Abstract

Objective: To study the metabolism of components in the Radix of Scutellaria baicalensis. Method: ① We established the HPLC fingerprint of water extract of S. baicalensis and real-time monitored the chemical composition. ②We established the HPLC fingerprint of water extract of S. baicalensis in vivo and analyzed the rats’ serum samples from hepatic portal vein with the established method. ③ We established the HPLC fingerprint of water extract of S. baicalensis in vivo and analyzed the rats’ serum samples from aorta abdominalis with the established method. ④ Intestinal absorption of S. baicalensis was investigated by everting gut sacs in rats＇sterile intestinal. ⑤ Using the established method

HPLC fingerprint spectrum of serum samples

the sample of herb

the sample after intestinal metabolism

rats’ serum samples from hepatic portal vein and rats’ serum samples from aorta abdominalis were investigated and analysed

in order to infer the metabolism of components in the Radix of S. baicalensis. Result: There were 17 compositions were detected

four of which were metabolized by intestinal flora and could not be absorbed into blood; four of them could not be absorbed directly into intestinal; seven compositions could be absorbed directly into intestinal; a new compound absorbed into blood while it was not detected in water extract of S. baicalensis. Conclusion: We could infer the metabolic processes of chemicals by analyzing and comparing HPLC fingerprint spectrum of serum samples

the sample of herb

the sample after intestinal metabolism

rats’ serum samples from hepatic portal vein and rats’ serum samples from aorta abdominalis.

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Related Institution

Department of Pharmacy,Zhujiang Hospital,Southern Medical University

Nanjing University of Chinese Medicine,Key Laboratory for Modern Research of Traditional Chinese Medical Formulae of Jiangsu

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