Effects of Ginseng Panaxadiol Saponins on Thromboxane B and 6-keto-prostaglandin F in Rats with Septic Shock

YU Lei; HUANG Min; WANG Jian-chun

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Effects of Ginseng Panaxadiol Saponins on Thromboxane B and 6-keto-prostaglandin F in Rats with Septic Shock

更新时间：2024-01-04

- Effects of Ginseng Panaxadiol Saponins on Thromboxane B and 6-keto-prostaglandin F in Rats with Septic Shock
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 16, Pages: 177-179(2011)
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- Published：2011
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YU Lei, HUANG Min, WANG Jian-chun. Effects of Ginseng Panaxadiol Saponins on Thromboxane B and 6-keto-prostaglandin F in Rats with Septic Shock[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(16): 177-179.
DOI：

YU Lei, HUANG Min, WANG Jian-chun. Effects of Ginseng Panaxadiol Saponins on Thromboxane B and 6-keto-prostaglandin F in Rats with Septic Shock[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(16): 177-179. DOI：

摘要

目的: 观察人参二醇组皂苷(PDS)对感染性休克大鼠肝中血栓素B2 (TXB2)及6-酮-前列腺素F1α(6-Keto-PGF1α)含量的影响

探讨其抗感染性休克的作用机制。方法: 动物随机分为对照(Control)组;内毒素休克(LPS)组;地塞米松(LPS+Dex 2 mg·kg-1)组;人参二醇组皂苷(LPS+PDS)组。LPS+PDS组iv人参二醇组皂苷(22.5

90 mg·kg-1)葡萄糖溶液5 mL·kg-1。10 min后iv细菌内毒素(LPS

5 mg·kg-1)复制感染性休克模型。颈动脉插管记录平均动脉压(MAP)。休克后4 h处死动物

称取肝20 mg匀浆后测TXB2和6-keto-PGF1α的含量。结果: 注射内毒素后

LPS组的MAP迅速下降

在低水平维持

LPS+Dex组和LPS+PDS组的MAP未见明显下降;测得肝组织中TXB2和6-keto-PGF1α的含量在LPS+PDS中、大剂量组均显著低于LPS组

6-Keto-PGF1α/TXB2在中剂量组显著低于LPS组。结论: PDS可通过降低体内TXA2和PGI2的含量

调节血浆或组织中二者的平衡关系

改善内毒素休克大鼠的低血压状态

起到抗休克的作用。

Abstract

Objective: To observe the effects of ginseng panaxadiol saponins (PDS) on thromboxane B2 (TXB2) and 6-keto-prostaglandin F1α(6-Keto-PGF1α) in rat model of endotoxic shock. Method: Sixty rats were divided into 6 groups randomly:groups under the names of lipopolysaccharides (LPS)

LPS+dexamethasone (DEX

2 mg·kg-1)

LPS+PDS (22.5 mL·kg-1)

LPS+PDS (45 mL·kg-1)

LPS+PDS (90 mL·kg-1) and control group respectively. PDS was injected into ranine vein ten minutes after septic shock model was induced by injection of LPS (4 mg·kg-1). MAP was measured through carotid arterial cannula. Animals were killed after 4 hours and their livers (20mg each) were taken for homogenate. PGF1α and TXB2 were measured using radioimmunoassay kit. Result: MAP in LPS group was decreased significantly after injection of LPS and maintained at lower level. While MAPs of LPS+DEX

LPS+PDS were not shown obviously decrease. PGF1α and TXB2 of LPS+PDS group were decreased obviously with comparison to LPS group. Conclusion: PDS plays the role of anti-shock through decreasing the levels of PGF1α and TXB2 in rats with septic shock.

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