Determination of Soluble Arsenic in Niuhuang Jiedu Tablets and Its Disassembled Presciption by AFS

DONG Ju; CHEN Hui; WU Juan; WANG Ming-yan; ZHAN Zhen

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Determination of Soluble Arsenic in Niuhuang Jiedu Tablets and Its Disassembled Presciption by AFS

更新时间：2024-01-04

- Determination of Soluble Arsenic in Niuhuang Jiedu Tablets and Its Disassembled Presciption by AFS
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 18, Pages: 67-70(2011)
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- Published：2011
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DONG Ju, CHEN Hui, WU Juan, et al. Determination of Soluble Arsenic in Niuhuang Jiedu Tablets and Its Disassembled Presciption by AFS[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(18): 67-70.
DOI：

DONG Ju, CHEN Hui, WU Juan, et al. Determination of Soluble Arsenic in Niuhuang Jiedu Tablets and Its Disassembled Presciption by AFS[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(18): 67-70. DOI：

摘要

目的: 探讨牛黄解毒片配伍对有毒中药雄黄是否具有减毒作用及其可能减毒药味。方法: 设立牛黄解毒片全方及其不同拆方组

分别用人工胃液或人工肠液处理

然后采用原子荧光光谱法测定并比较不同组可溶性砷的含量。结果: 人工胃液或人工肠液处理后

牛黄解毒片全方组可溶性砷含量明显低于单味雄黄组(P<0.01);牛黄解毒片全方去甘草、黄芩、大黄组可溶性砷含量明显高于牛黄解毒片全方组(P<0.01)。结论: 牛黄解毒片全方配伍对雄黄有减毒作用

并且甘草、黄芩、大黄是减毒的可能药味。

Abstract

Objective: To explore whether the compatibility of Niuhuang Jiedu tablets could reduce the toxicity of realgar

and which may be the possible herbal medicines that could reduce toxicity in the Niuhuang Jiedu tablets prescription. Method: Different groups about Niuhuang Jiedu Tablets and its disassembled prescription were arranged

treated with artificial gastric juice or artificial intestine juice

and then atom fluorescence spectrophotometry (AFS) was used to detect the content of soluble arsenic in the different groups samples. Result: The content of soluble arsenic in the whole prescription was significant lower than that in the single realgar (P<0.01). The content of soluble arsenic in the whole prescription except for Gancao

Huangqin and Dahuang was significant higher than that in the whole prescription (P<0.01). Conclusions: The compatibility for Niuhuang Jiedu tablets could reduce the toxicity of realgar

and Gancao

Huangqin and Dahuang may be the possible herbal medicines that could reduce toxicity.

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