Effects of Total Saponins of  on Blood Lipid Metabolism in Rats with Experimental Hyperlipidemia

LIU Fei; CHEN Hong; ZHONG Ming; WEI Li-li; LIU Chun-li; LIU Chun-yang

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Effects of Total Saponins of on Blood Lipid Metabolism in Rats with Experimental Hyperlipidemia

更新时间：2024-01-04

- Effects of Total Saponins of on Blood Lipid Metabolism in Rats with Experimental Hyperlipidemia
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 14, Pages: 211-214(2011)
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- Published：2011
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LIU Fei, CHEN Hong, ZHONG Ming, et al. Effects of Total Saponins of on Blood Lipid Metabolism in Rats with Experimental Hyperlipidemia[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(14): 211-214.
DOI：

LIU Fei, CHEN Hong, ZHONG Ming, et al. Effects of Total Saponins of on Blood Lipid Metabolism in Rats with Experimental Hyperlipidemia[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(14): 211-214. DOI：

摘要

目的: 建立高血脂症大鼠模型

观察毕岱总皂苷(BD-TAS)对高血脂症大鼠血脂代谢的影响。方法 :健康成年雄性SD大鼠60只

随机分为正常对照组(NC)

高脂模型组(HC)

血脂康对照组

毕岱总皂苷组(BD-TAS

低、中、高剂量组);除NC组

其余各组高脂饲料喂养8周

建立高脂血症大鼠模型;从模型复制成功后第0周开始

NC组和HC组均ig等量生理盐水

BD-TAS低、中、高剂量组(4

12 g ·kg-1)和血脂康对照组(0.5 g ·kg-1)均ig给药

并在第0

6周后称量体重

眼眶取血

离心取血清

用酶法测定血浆中胆固醇(TC)、甘油三酯(TG)和高密度脂蛋白胆固醇(HDL-C)的水平以及血清和肝脏丙二醛(MDA)水平

评价BD-TAS对高血脂症大鼠血脂代谢和肝脏保护作用。结果 :以高脂饲料喂养大鼠8周后

与NC组相比

HC组TC

HDL-C和LDL-C均升高且有显著性差异(P＜0.01)

成功复制了混合型高脂血症大鼠模型。以不同剂量BD-TAS溶液ig后

各组血浆TC

TG水平与高脂模型组比较

在第2

6周具有显著性差异(P＜0.05或P＜0.01);与NC组和HC比较

BD-TAS低、中剂量组TC

TG水平降低明显(P＜0.05);BD-TAS高剂量组与低剂量组比较

TG水平具有显著性差异(P＜0.01)。与NC组比较

BD-TAS给药组血清MDA差异显著(P＜0.05)。结论 :BD-TAS摄入量越大

其改善血脂水平的效果越好

显示出明显的剂量依赖关系

提示毕岱总皂苷具有降血脂的作用

而且具有一定的肝保护作用。

Abstract

Objective: To establish hyperlipidemia model of rats

to observe total saponins of Medicago sative(BD-TAS) on blood lipid metabolism in hyperlipidemia rats. Method : Sixty SD rats were randomly divided into six groups: normal control group (NC)

high-lipid model group (HC)

Xuezhikang capsule group

and BD-TAS group. All groups were induced with high fat diet for 8 weeks except NC

to establish hyperlipemia. NC and HC group were ig physiological saline

BD-TAS (4

12 g ·kg-1)

Xuezhikang Capsule group(0.5 g ·kg-1). The contents of TC

LDL-C

HDL-C and MDA were examined four times in the plasma after 0

6 weeks. Result : The result showed that with high fat diet after 8 weeks

compared with NC group

HDL-C and LDL-C were increased significantly (P < 0.05)

so hyperlipidemia rat model was established successfully. BD-TAS of different dose groups

TC and TG in plasma were reduced after 2

6 weeks

compared with HC group (P<0.05). The level of TC in low-dose BD-TAS group was statistically significant compared with Xuezhikang group (P<0.05) and the levels of TC

TG in high-dose BD-TAS group were statistically significant compared with low-dose BD-TAS group (P<0.05). Conclusion : The levels of TC

TG and MDA decreased with the increased of BD-TAS dose

indicating a clear dose-effect relationship. BD-TAS is effective in modulating the blood lipid levels.

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