Study on Intestinal Absorption of Lutein Microscapsules in Rats by Single Pass Perfusion Method
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Study on Intestinal Absorption of Lutein Microscapsules in Rats by Single Pass Perfusion Method
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 18, Pages: 133-136(2011)
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Published:2011
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LU Ping, WANG Xin-chun, CHEN Wen, et al. Study on Intestinal Absorption of Lutein Microscapsules in Rats by Single Pass Perfusion Method[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(18): 133-136.
DOI:
LU Ping, WANG Xin-chun, CHEN Wen, et al. Study on Intestinal Absorption of Lutein Microscapsules in Rats by Single Pass Perfusion Method[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(18): 133-136.DOI:
Study on Intestinal Absorption of Lutein Microscapsules in Rats by Single Pass Perfusion Method
Objective: To study the in situ intestinal absorption behaviors of lutein microscapsules in rats. Method: In situ the rat single-pass intestinal perfusion model was used and the concentrations of the perfusate were determined by UV to investagate the intestinal absorption site and mechanism. Result: The Ka and Papp of Lutein Microscapsules showed ileum>jejunum>duodenum>colon in four different region of rat intestine. The Ka and Papp between four intestinal segments had no significant influence. The Ka and Papp of different drug concentration had no significant influence. Conclusion: Lutein Microscapsules could be absorbed in whole intestinal segment
drug concentration had no effect to Ka and Papp
its absorbing mechanism may be for passive diffusion.
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