Objective: To investigate the effects of Huashi Liquid on the content of D-xylose and ghrelin in serum of rats with dampness retention syndrome. Method: Forty SD rats were randomly divided into normal group

model group and Huashi liquid of high

middle and low-dose groups

with 8 rats in each group.Dampness retention syndrome was induced in all rats

except the normal group

by modified enviromental and fatigue method for 6 days.After the model was formed

the normal and model groups were fed with saline(NS)in 20 mL ·kg-1 dose

Huashi liquid of high

middle and low-dose groups were fed Huashi liquid in different dose(4

8

16 g ·kg-1)respectively

once time per day for 8 days. Then the content of D-xylose in serum was detected with colorimetric method

and the content of ghrelin in serum was detected with double-antibody sandwich enzyme-linked immunosorbent assay(ELISA). Result: The splenic asthenia symptom was significant

D-xylose(P<0.01)and ghrelin(P<0.05)were decreased and the hyperaemia

edema in the gastric mucosa existed in model group

compared with the normal group.In gastric mucosa of all the Huashi liquid

symptom such as hyperaemia

and edema were disappeared

the splenic asthenia symptom improved

D-xylose(P<0.05)and ghrelin(P<0.01)significantly increased

compared with the normal group. Conclusion: Huashi liquid could improve the splenic asthenia symptom and repair the gastric mucosa

the mechanism maybe related to increasing in D-xylose and ghrelin in serum.