Experimental study on the effect of dosage form and administration route to the distribution of Ginsenoside Rg1 in serum and brain of the rats
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Experimental study on the effect of dosage form and administration route to the distribution of Ginsenoside Rg1 in serum and brain of the rats
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 14, (2011)
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Published:2011
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chen xin mei. Experimental study on the effect of dosage form and administration route to the distribution of Ginsenoside Rg1 in serum and brain of the rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(14).
DOI:
chen xin mei. Experimental study on the effect of dosage form and administration route to the distribution of Ginsenoside Rg1 in serum and brain of the rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(14).DOI:
Experimental study on the effect of dosage form and administration route to the distribution of Ginsenoside Rg1 in serum and brain of the rats
Objective: To discuss the effect of dosage form and administration route to the distribution of ginsenoside Rg1 in serum and brain of the rats. Methods: Compared with ginsenoside Rg1 saline solution administrated from nasal route and oral route
ginsenoside Rg1 nasal spray was administrated from nasal route in rats. The concentration of ginsenoside Rg1 in the serum and brain was detected by HPLC-UV. The data was analysised by the Wagner-Nelson method. Results: The distribution and transport efficiency of ginsenoside Rg1 was improved 5.05 and 2.50 times respectively by nasal administration route. The distribution and transport efficiency of ginsenoside Rg1 was improved 11.80 and 3.35 times respectively by nasal spray. Conclusion: The bio-availability of ginsenoside Rg1 can be improved dramatically by the nasal administration route and nasal spray.