Therapeutic Effects of the Combination of Ibuprofen and Dihydroartemisinin on Rat Adjuvant Arthritis and Its Mechanism
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Therapeutic Effects of the Combination of Ibuprofen and Dihydroartemisinin on Rat Adjuvant Arthritis and Its Mechanism
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 9, Pages: 177-180(2011)
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Published:2011
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YI Jian-feng. Therapeutic Effects of the Combination of Ibuprofen and Dihydroartemisinin on Rat Adjuvant Arthritis and Its Mechanism[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(9): 177-180.
DOI:
YI Jian-feng. Therapeutic Effects of the Combination of Ibuprofen and Dihydroartemisinin on Rat Adjuvant Arthritis and Its Mechanism[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(9): 177-180.DOI:
Therapeutic Effects of the Combination of Ibuprofen and Dihydroartemisinin on Rat Adjuvant Arthritis and Its Mechanism
Objective: To study the therapeutic effects of the combination of ibuprofen and dihydroartemisinin on rheumatoid arthritis in rats
and to explore the compatible mechanism of the drugs. Method: Standard Sprague Dawley rats with weight of 160-180 g were randomly divided into 7 groups
including normal group
adjuvant arthritis (AA) model group
methotrexate group
Compatibility high-dose group
Compatibility low-dose group
ibuprofen group
dihydroartemisinine group. We detected T-lymphocyte subsets in peripheral blood by flow cytometry
and measured the levels of INF-γ and IL-4 in serum by ELISA for AA animal model treated by drugs. Result: The combination group could significantly reduced the percentage of CD+ 4 T cells and CD+4 T/ CD+8T ratio in the peripheral blood lymphocytes cells
reduce INF-γ and improve IL-4 in serum. Compared with the ibuprofen group
dihydroartemisinin could significantly improve IL-4 (P<0.01). The combination of the drugs could more effectively delay the joint injury of the model rats compared with those given individual drug. Conclusion: The combination of ibuprofen with dihydroartemisinin can suppress proliferation of CD4 + T cells
and promote the Th1/Th2 shift towards the Th2 cytokine response
and can complement
thus enhancing the therapeutic effect for arthritis.
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Related Author
LIANG Tingjun
ZHANG Guoxin
LIU Ying
ZHU Chunyan
LIN Na
YANG Yibo
XU Ying
WANG Lu
Related Institution
Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences
School of Pharmacy,Fujian University of Traditional Chinese Medicine
Anhui University of Chinese Medicine
Artemisinin Research Centre,China Academy of Chinese Medical Sciences
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine