Pharmacokinetic Study of Aurapetene after Intravenous Injection in Rats
|更新时间:2024-01-04
|
Pharmacokinetic Study of Aurapetene after Intravenous Injection in Rats
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 18, Pages: 130-133(2011)
作者机构:
作者简介:
基金信息:
DOI:
CLC:
Published:2011
稿件说明:
移动端阅览
YUAN Jin-bin, WANG Fa-ying, LI Ming, et al. Pharmacokinetic Study of Aurapetene after Intravenous Injection in Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(18): 130-133.
DOI:
YUAN Jin-bin, WANG Fa-ying, LI Ming, et al. Pharmacokinetic Study of Aurapetene after Intravenous Injection in Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(18): 130-133.DOI:
Pharmacokinetic Study of Aurapetene after Intravenous Injection in Rats
Objective: To develop a simple HPLC method for the determination of auraptene in rats plasma
and to investigate the pharmacokinetics of auraptene after intravenous injection in rats. Method: The contents of auraptene in rats plasma were determined by RP-HPLC. The software DAS 2.1 was used to calculate the pharmacokinetic parameters. Result: After intravenous injection to rats
direct proportion was found between AUC and the doses
and linear relationship was observed between Cmax and the doses. MRT did not extend with the doses
but the half-life time changed. Conclusion: The pharmacokinetics of auraptene after intravenous injection in rats are in accord with two-compartment model
the disposal process fits incompletely linear kinetics.
Pharmacokinetics of Paeonol from Tiangou Jiangya Capsule in Rats
Pharmacokinetics of Shuanghuanglian Powder Injection in Rats
Pharmacokinetics of Breviscapine Tablets in Healthy Volunteers
Related Author
Liu Hong
HAO Yu
ZHU Xiao-yue
WANG Meng
ZHANG De-qin
JIANG Yan
ZHANG Wei
LIN Xiu-yan
Related Institution
Third Affiliated Hospital of Qiqihar Medical College
Fourth affiliated hospital of Qiqihar Medical College
Research Institute of Tianjin University of Traditional Chinese Medicine,Key Laboratory of Traditional Chinese Medical Formulation in Ministry of Education
School of Life Sciences,Beijing University of Chinese Medicine
School of Pharmacy,Shanghai University of Traditional Chinese Medicine