Objective: To explore the mechanism of the domestic β-aescin treating chronic venous insufficiency through observing its actions on the isolated canine saphenous venous tension

venous pressure

venous return and lymphatic drainage. Method: The isolated canine spiral saphenous uenous tension test was performed to detect the activity of the β-aescin.Furthermore

in the comdition of constant canine femoral artery perfusion kept in the extracorporeal circulation

we measured the changes in the canine femoral artery pressure

femoral artery artery flow and the lymphatic drainage flow after intravenous injection of the drug. Result: When β-aescin was administrated at the dose between 5.0×10-5-5.25×10-6g ·mL-1

it could obviously increase the contractile tension of the venous to norepinephrine in a dose-dependent manner.With canine femoral artery perfusion kept constant

β-aescin

whose doses were 50 mg and 100 mg

could reinforce intently the canine femoral venous tension

accelerate the rise of the venous return and lymphatic drainage. Conclusion: The domestic β-aescin extracted from shorea has some therapeutical effect on chronic venous insufficiency by strengthening the venous tension

increasing the venous pressure and promoting venous return and lymphatic drainage.