Effect of Modfidy Sisi Erhefang on Gouty Nephropathy

ZHANG Han-xin; MA Zhi-heng; SHI Zhi-qin; HUANG Mei-qin; WANG Heng; WANG Jin

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Effect of Modfidy Sisi Erhefang on Gouty Nephropathy

更新时间：2024-01-04

- Effect of Modfidy Sisi Erhefang on Gouty Nephropathy
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 16, Pages: 248-250(2011)
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- Published：2011
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ZHANG Han-xin, MA Zhi-heng, SHI Zhi-qin, et al. Effect of Modfidy Sisi Erhefang on Gouty Nephropathy[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(16): 248-250.
DOI：

ZHANG Han-xin, MA Zhi-heng, SHI Zhi-qin, et al. Effect of Modfidy Sisi Erhefang on Gouty Nephropathy[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(16): 248-250. DOI：

摘要

目的: 观察加减"四四二合方"治疗原发性痛风性肾病(湿热痰浊瘀血内阻型)的临床疗效。方法: 104例原发性痛风性肾病(湿热痰浊、瘀血内阻型)的患者随机分为治疗组58例和对照组46例

两组一般治疗相同

治疗组另外予加减四四二合方

对照组给予别嘌呤醇。治疗8周后观察两组患者的症状

体征以尿酸(UA)

肌酐(Cre)

尿素(UN)

β2-微球蛋白(β2-M)

24 h尿蛋白的变化。结果: 治疗组

对照组总有效率分别为84.5%

71.8%

两组比较有显著性差异(P<0.05)

治疗前后各组内比较

两组的UA

CRE

β2-MG

24 h尿蛋白均有所好转(P<0.05或P<0.01)

治疗后组间比较

部分指标也有显著性差异 (P<0.05或P<0.01)

治疗组总体优于对照组。结论: 加减"四四二合方"对原发性痛风性肾病有较好的临床疗效。

Abstract

Objective: To investigate the effect of modfidy Sisi Erhefang on gouty nephropathy. Method: One hundred and four patients with gouty nephropathy were randomized into two groups

58 patients in the treated group were treated with modfidy Sisi Erhefang

and 46 patients in the control group were treated with allopurinol

symptom

uric acid(UA)

creatinine(Cre)

urea nitrogen(UN) β2-microglobulin (β2-M) and 24 h urine protein of patiens in two groups were measured before and after treatment for 8 weeks. Result: Improvements of symptoms and decreasing of UA

Cre

β2-MG and 24 h urine protein in the treated group was superior to those in the control group(P<0.05 or P<0.01). Conclusion: Modfidy Sisi Erhefang present good effect in treating gouty nephropathy.

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Related Institution

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