Study on Effects of Tongbi Paizhuo Proved Recipe of Miao Nationality Medicine on Anti-gouty Arthritis and its Formulating Principle

YUN Xue-lin; YANG Bi-xian; HU Qi-zhi; ZHU Yan

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Study on Effects of Tongbi Paizhuo Proved Recipe of Miao Nationality Medicine on Anti-gouty Arthritis and its Formulating Principle

更新时间：2024-01-04

- Study on Effects of Tongbi Paizhuo Proved Recipe of Miao Nationality Medicine on Anti-gouty Arthritis and its Formulating Principle
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 14, Pages: 192-195(2011)
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- Published：2011
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YUN Xue-lin, YANG Bi-xian, HU Qi-zhi, et al. Study on Effects of Tongbi Paizhuo Proved Recipe of Miao Nationality Medicine on Anti-gouty Arthritis and its Formulating Principle[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(14): 192-195.
DOI：

YUN Xue-lin, YANG Bi-xian, HU Qi-zhi, et al. Study on Effects of Tongbi Paizhuo Proved Recipe of Miao Nationality Medicine on Anti-gouty Arthritis and its Formulating Principle[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(14): 192-195. DOI：

摘要

目的: 探讨基于苗医药理论指导下通痹降浊验方的组方原则

研究该验方对动物痛风性关节炎的药效作用。方法 :将Wistar大鼠

按每组10只随机分为NS组、阳性药阿司匹林0.25 g ·kg-1对照组、通痹排浊验方高(6 g ·kg-1)、低剂量组(3 g ·kg-1)及模型组。ig给药

分别按照5 d

11 d给药后

测定大鼠足跖肿胀率及大鼠血清尿酸水平。观察对小鼠化学刺激痛和热板刺激痛的镇痛作用。结果 :通痹排浊验方高剂量组、阳性药对照组对MSU引起的足跖肿胀有显著的消肿作用(P＜0.01);低剂量组能明显减轻MSU引起的大鼠足跖肿胀(P<0.05)。通痹降浊验方高、低剂量组均能显著降低急性痛风性关节炎大鼠的血尿酸水平(P<0.01);该验方对小鼠化学刺激痛和热板刺激痛有一定的镇痛作用。结论 :通痹排浊验方具有降低血清尿酸水平、减轻痛风性关节炎足跖肿胀及一定的镇痛作用。苗医治疗热风湿类病证"以藤为通"、"降浊泄乱"的组方原则对治疗痛风性关节炎具有一定的借鉴意义。

Abstract

Objective: To investigate formulating principle based on Miao nationality medicine theory of Tongbi Paizhuo proved recipe(TBPZ)

study the medicine efficacy to treat acute gouty arthritis. Method : Wistar rats were divided into groups (n=10 each) at random

the group is respectively normal

positive control medicine

TBPZ high dose (6 g ·kg-1)

TBPZ low dose (3 g ·kg-1) and model. Rat model of acute gouty arthritis was established by MSU intraarticular injection. Medicines were ig given separately for 5 days or 11 days according to experimental requirements. Toe swelling rate and serumuric acid level in rats were determined. Analgesic effect of the recipe was evaluated by mice stimulated with acetic acid or hot plate. Result : TBPZ high dose group and positive control medicine group could reduced toe swelling rate markedly (P<0.01)

the low dose could reduced toe swelling rate obviously (P<0.05). TBPZ high and low dose both could reduce the serumuric acid level markedly in acute gouty arthritis rat (P<0.01)

which proved recipe had analgesic effect significantly in mice stimulated by acetic acid or hot plate. Conclusion : TBPZ could significantly reduce the serumuric acid level and toe swelling rate in acute gouty arthritis rat

and has certain analgesic effect in mouse. Formulating principle

such as 'using vine to activating blood circulation’ and 'excrete zhuo and luan’ of Miao nationality medicine for treating thermal- rheumatic

can be used as a reference to treat gouty arthritis.

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Related Institution

Institute of Chinese Medicine，Heilongjiang University of Chinese Medicine

Graduate School of Heilongjiang University of Chinese Medicine

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