Effect of Jingyuankang Capsule on Expression of Bcl-2, Bax mRNA in Bone Barrow Cells of Model Mice of Chemotherapy-induced Myelosuppression
|更新时间:2024-01-04
|
Effect of Jingyuankang Capsule on Expression of Bcl-2, Bax mRNA in Bone Barrow Cells of Model Mice of Chemotherapy-induced Myelosuppression
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 11, Pages: 216-219(2011)
作者机构:
作者简介:
基金信息:
DOI:
CLC:
Published:2011
稿件说明:
移动端阅览
JIANG Li-feng, JIANG Shi-qing. Effect of Jingyuankang Capsule on Expression of Bcl-2, Bax mRNA in Bone Barrow Cells of Model Mice of Chemotherapy-induced Myelosuppression[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(11): 216-219.
DOI:
JIANG Li-feng, JIANG Shi-qing. Effect of Jingyuankang Capsule on Expression of Bcl-2, Bax mRNA in Bone Barrow Cells of Model Mice of Chemotherapy-induced Myelosuppression[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(11): 216-219.DOI:
Effect of Jingyuankang Capsule on Expression of Bcl-2, Bax mRNA in Bone Barrow Cells of Model Mice of Chemotherapy-induced Myelosuppression
Objective: To observe the effect of Jingyuankang capsule on the expression of Bcl-2
Bax mRNA in bone marrow cells of model mice of chemotherapy-induced myelosuppression and make a further study of the mechanism of the medicine. Method: Measuring the expression of Bcl-2
Bax mRNA in bone marrow cells of model mice of myelosuppression with real-time fluorescence quantitative PCR. Result: The Jingyuankang group had the highest expression of Bcl-2 mRNA and lowest expression of Bax mRNA
compared with the model group
the difference was significant
while compared with the control group
there was no significant differences. Conclusion: These results confirmed preliminarily that Jingyuankang capsule could increase the expression of the anti-apoptotic gene Bcl-2 and decrease the expression of proapoptotic gene Bax
through affecting the apoptosis-related pathway to prevent the blood cells from apoptosis caused by chemotherapy
this may be an important mechanism.of Jingyuankang capsule treating the chemotherapy-induced myelosuppression.
Effect of Jingyuankang Capsule on Expression of Apoptosis-related Genesin Bone Barrow Cells of Model Mice of Chemotherapy-induced Myelosuppression
Astragali Radix-Salviae Miltiorrhizae Radix et Rhizoma Ameliorates Myocardial Ischemia-reperfusion Injury in Rats via FUNDC1-dependent Mitophagy
Hei Xiaoyaosan Improves Learning and Memory Abilities in Alzheimer's Disease Rats by Regulating Cell Apoptosis
Renshen Yangrongtang Alleviating Myelosuppression by Reducing Neutrophil Extracellular Traps Through Regulating ROS/MPO
Mechanism of Gushining Granules in Attenuating Dexamethasone-induced Apoptosis of Bone Marrow Mesenchymal Stem Cells via Activating PI3K/Akt/Bad Signalling Pathway
Related Author
SANG Feng
JIANG Shi-qing
LIU Yan-qing
WANG Zhe
WANG Guoliang
WANG Ziyi
HAO Qianying
HE Qingyong
Related Institution
Wangjing Hospital of China Academy of Chinese Medical Sciences
Beijing University of Chinese Medicine
Xiyuan Hospital, China Academy of Chinese Medical Sciences
Guang'anmen Hospital, China Academy of Chinese Medical Sciences
Gansu Engineering Laboratory for New Products of TCM