Inhibitory Effect of LAMS Against Prostatic Cancer in Tumor-earing Mice

ZOU Ming-chang; SHENG Yu-qing; CUI Fei-lun

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Inhibitory Effect of LAMS Against Prostatic Cancer in Tumor-earing Mice

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- Inhibitory Effect of LAMS Against Prostatic Cancer in Tumor-earing Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 17, Pages: 223-225(2011)
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- Published：2011
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ZOU Ming-chang, SHENG Yu-qing, CUI Fei-lun. Inhibitory Effect of LAMS Against Prostatic Cancer in Tumor-earing Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(17): 223-225.
DOI：

ZOU Ming-chang, SHENG Yu-qing, CUI Fei-lun. Inhibitory Effect of LAMS Against Prostatic Cancer in Tumor-earing Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(17): 223-225. DOI：

摘要

目的: 研究昆布多糖硫酸酯(LAMS)对移植前列腺癌细胞RM-1荷瘤小鼠的抑瘤作用。方法: C57小鼠接种前列腺癌RM-1细胞7 d后

按瘤体大小将40只小鼠均分为4组

分别为模型组(NS)

环磷酰胺(CY)组(20 mg ·kg-1)

LAMS低、高剂量组(50

100 mg ·kg-1)

1次/d

连续14 d

停药次日称体质量并处死动物

剥取瘤块

摘取脾脏和胸腺

称质量

计算抑瘤率、脾指数和胸腺指数。结果: CY 20 mg ·kg-1抑瘤率为40.3%

LAMS低、高剂量组抑瘤率分别为25.0%和33.8%

与模型组比较均有显著差异;CY在抑瘤的同时能显著抑制荷瘤小鼠的胸腺指数和脾指数

与模型组比较有显著性差异

LAMS对荷瘤小鼠的胸腺指数和脾指数无明显影响。结论: LAMS对移植前列腺癌RM-1的荷瘤小鼠有一定的抑瘤作用

LAMS在抑制肿瘤的同时不影响荷瘤鼠的免疫功能

无CY等化疗药物的常见副作用。

Abstract

Objective: To study the inhibitory effect of LAMS on prostatic cancer growth in tumor-bearing mice. Method: Fourty C57 mice inoculated with RM-1 prostate cancer cells for 7 days were divided into 4 groups according to the tumor size:the model group (NS)

cyclophosphamide (CY) group (20 mg ·kg-1)

LAMS low and high dose groups (50

100 mg ·kg-1)

once daily. After 14 days of treatment

the animals were killed. The subcutaneous sarcoma

thymus and spleen were separated and weighted. Inhibition rate

spleen index and thymus index were then calculated. Result: CY 20 mg ·kg-1 significantly inhibited the growth of tumor

the inhibition rate was 40.3%;LAMS(low and high dose) also showed significant inhibitory effect compared with the model group

the inhibition rates were 25.0% and 33.8%. CY could significantly inhibited the thymus index and spleen index in tumor-bearing mice

however

the effects of LAMS were not significant. Conclusion: LAMS have inhibitory effects on RM-1 in tumor-bearing mice

but do not affect the immune function. Furthermore

LAMS has no side effects on chemotherapy drugs such as CY.

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