Protective Effect of Total Salvianolic Acids on Myocardium Injury Induced by Ischemia-reperfusion in Isolated Rat Heart

CHEN Wen; GUO Li-li; ZHOU Ting-ting; WANG Jie; CUI Han-ming

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Protective Effect of Total Salvianolic Acids on Myocardium Injury Induced by Ischemia-reperfusion in Isolated Rat Heart

更新时间：2024-01-04

- Protective Effect of Total Salvianolic Acids on Myocardium Injury Induced by Ischemia-reperfusion in Isolated Rat Heart
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 9, Pages: 173-176(2011)
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- Published：2011
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CHEN Wen, GUO Li-li, ZHOU Ting-ting, et al. Protective Effect of Total Salvianolic Acids on Myocardium Injury Induced by Ischemia-reperfusion in Isolated Rat Heart[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(9): 173-176.
DOI：

CHEN Wen, GUO Li-li, ZHOU Ting-ting, et al. Protective Effect of Total Salvianolic Acids on Myocardium Injury Induced by Ischemia-reperfusion in Isolated Rat Heart[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(9): 173-176. DOI：

摘要

目的: 观察丹参总酚酸(TSA) 对离体大鼠心肌缺血再灌注(I/R)心脏的保护作用。方法: 采用Langendorff 离体心脏恒压灌流模型

大鼠分为空白对照组、模型组、停灌前给药组、复灌给药组。停灌前给药组为正常灌流平衡20 min后

分别用质量浓度0.2

0.1 g ·L-1的TSA灌流液灌注10 min

停灌31 min

复灌30 min

用于观察TSA对再灌后心律失常的影响;复灌给药组正常灌流平衡30 min

停灌31 min

复灌分别给予质量浓度0.2

0.1 g ·L-1 TSA灌流液15 min

再用正常灌流液灌注15 min

用于观察TSA对心功能的影响。结果: 停灌前给药

TSA 能明显减少I/R后大鼠心律失常发生次数和持续时间(P<0.05~0.01);复灌后给药

与模型相比TSA高剂量组可显著减轻缺血再灌注诱导的冠脉流量

左室发展压(LVDP)

左室内压最大变化速率(±dp/dtmax)下降

左室舒张末压(LVEDP)的升高(P<0.05~0.01)

低剂量组仅冠脉流量

+dp/dtmax的恢复高于模型组(P<0.05)。结论 :TSA 能减轻离体心脏缺血再灌注诱导的冠脉损伤

促进复灌心肌功能恢复

具有明显保护作用。

Abstract

Objective: To observe the direct protective effect of total salvianolic acids(TSA) on myocardium injury induced by ischemia-reperfusion in isolated rat heart. Method: Heart ischemia-reperfusion model was induced in the isolated rat heart subjected to 31 min ischemia and 30 min reperfusion at constant pressure. The left ventricular pressure(LVP)

coronary flow(CF) were recorded and the influences of different doses of TSA in KH solution on the changes of heart function parameter were observed. Result: TSA treated hearts showed significant recovery of post-ischemic contractile function(The levels of LVDP

±dp/dtmax

CF and LVEDP(P<0.05-0.01). Conclusion: TSA has direct protective effect on myocardium injury induced by ischemia-reperfusion.

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