Preparation and Release Test  of Xiaojin Sustained Release Pellets

LIU Wen-yong; LI Dong-xun; GUAN Zhi-yu; ZHANG Guo-song; LIU Hong-ning; LUO Xiao-jian

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Preparation and Release Test of Xiaojin Sustained Release Pellets

更新时间：2024-01-04

- Preparation and Release Test of Xiaojin Sustained Release Pellets
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 18, Pages: 22-25(2011)
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- Published：2011
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LIU Wen-yong, LI Dong-xun, GUAN Zhi-yu, et al. Preparation and Release Test of Xiaojin Sustained Release Pellets[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(18): 22-25.
DOI：

LIU Wen-yong, LI Dong-xun, GUAN Zhi-yu, et al. Preparation and Release Test of Xiaojin Sustained Release Pellets[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(18): 22-25. DOI：

摘要

目的: 制备小金缓释微丸

并以阿魏酸为指标

考察不同包衣条件下小金缓释微丸的体外释放度。方法: 采用单因素试验优选包衣工艺。结果: 以乙基纤维素为包衣材料

包衣增重10%

致孔剂乳糖的用量为12%

可满足10 h缓释的要求。结论: 包衣材料、包衣增重以及致孔剂的用量是影响药物释放的关键因素。

Abstract

Objective: To prepare Xiaojin sustained release pellets and investigate release in vitro of Xiaojin sustained release pellets with different coating conditions by ferulic acid was determined as index. Method: Single factor test was applied to optimize the coating formulations. Result: A 10 h-sustained release curve was satisfactorily obtained by using EC as coating material and lactose 12% as porogenic agent in the optimized coating formulation with a 10% of coating weight gained. Conclusion: Coating material

coating weight gained and the amount of porogenic agent are the key factors that can significantly affect the drug release in vitro .

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