Influences of Yuanzhi Qingnao Keli on Learning and Memory Ability andBiochemical Indexes in Mice with Alzheimer’s Disease
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Influences of Yuanzhi Qingnao Keli on Learning and Memory Ability andBiochemical Indexes in Mice with Alzheimer’s Disease
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 12, Pages: 185-187(2011)
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Published:2011
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YU Xing-hua, LI Tao, LI Chang-wei. Influences of Yuanzhi Qingnao Keli on Learning and Memory Ability andBiochemical Indexes in Mice with Alzheimer’s Disease[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(12): 185-187.
DOI:
YU Xing-hua, LI Tao, LI Chang-wei. Influences of Yuanzhi Qingnao Keli on Learning and Memory Ability andBiochemical Indexes in Mice with Alzheimer’s Disease[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(12): 185-187.DOI:
Influences of Yuanzhi Qingnao Keli on Learning and Memory Ability andBiochemical Indexes in Mice with Alzheimer’s Disease
Objective: To observe the influence of Yuanzhi Qingnao Keli (YZQNKL) on learning and memory ability and biochemical indexes in dementia model of mouse. Method: This research used ICR mice
injected D-gal and the nitric acid sodium lead to induce dementia in mice. Treatments were carried out with drugs. The maze was used to evaluate the learn ability of mice. The brain tissue biochemical indexes(SOD GSH-Px and MDA)were determined by spectrophotometry.Pathological dyeing and morphological examnation were carried out to investigate changes in cortex and hippocampal neurons. Result: YZQNKL of 750 mg ·kg-1 improved learning ability singnificantly compared with that of the controls (P< 0.01). YZQNKL of 750 mg ·kg-1 could obviously increase the levels of SOD (1.64±0.26)U ·mg-1
GSH-Px (0.297±0.051)U ·mg-1(P<0.01)and reduce MDA(2.71±0.80)μmol ·g-1in brain tissue(P<0.05). Conclusion: YZQNKL may improve learning and memory ability
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