Objective: To observe the effect of Xiaoer Zhike Granule on serum high mobility group box-1 protein(HMGB-1)level in lung tissues of mice with endotoxin shock. Method :ICR mice were divided into six groups

except the blank group

all other groups were injected with LPS by the tails vein to establish the lung tissue injury model. The blank group was only received an injection of same volume of saline. The serum HMGB-1 level at 24

36

48

72 and 96 h was investigated respectively to explore the time of the highest content. ICR mice were divided into six groups as follows:blank

model

Xiaoer Zhike Granule high

middle

low group

dexamethasone acetate tablets. The effect of Xiaoer Zhike Granule on serum HMGB -1 content of sepsis mice was studied at the point of 72 h. Result: Serum HMGB-1 got to the highest level at 72 h after injection of LPS. Xiaoer Zhike Granule could inhibit the content’s increase in HMGB-1(P<0.05). Conclusion: Xiaoer Zhike Granule can decrease serum HMGB-1’ content

which maybe related to its function.