Objective: To observe the therapeutic effects of Shengjiangsan on mesangial proliferative glomerulonephritis in rats. Method :Forty normal rats were randomly divided into control group

model group

Shengjiangsan group and Lotensin group. Except of the control group

the rats in last three groups were made as model of mesangial proliferative glomerulonephritis. From the fifth week

rats in Shengjiangsan group and Lotensin group were feed with Shengjiangsan 5.4 g ·kg-1 ·d-1

and Lotensin 1.17 mg ·kg-1 ·d-1 for eight weeks.respectively. Twenty four hours urine protein excretion was tested respectively before experiment

the forth week and the 12th week. After the 12 week

all the rats were executed. Kidneys were conserved to observe their pathological changes in different groups. Meanwhile NF-κB expression in kidney tissue was detected by immunohistochemistry. Result: The level of 24 hours urine protein(UP)

in the model group was higher compared with contral group(P＜0.01)

The levels in Shengjiangsan and Lotensin group were decreased(P<0.05). NF-κB expression in both glomerulus and renal interstitium in rats of model group was significant

and heavily expressed in nucleolus.But expressions in Shengjiangsan and Lotensin group were weaker. Conclusion: Shengjiangsan can reduce the urine protein excretion in rats with mesangial proliferative glomerulonephritis

decrease the expression of NF-κB in kidney tissue

and relieve hyperplasy of intercapillary cells and ground substance.