Objective: To oberseve the acute toxicity

anti-fatigue effect and anti-stress effect of Ginseng Tonic Decoction in mice. Method: Mice of KM species were used to test the maximum tolerance dose (MTD)of Ginseng Tonic Decoction. The mouse anti-fatigue test

the mouse acute cerebral ischemia anti-hypoxia test

the mouse anti-hypoxia test and the mouse resistant test to high and low-temperature were used to evaluate anti-stress effect of Ginseng Tonic Decoction at doses of 42.0

21.0 and 10.5 g ·kg-1 ·d-1. Result: the oral MTD of Ginseng Tonic Decoction in mice was>160 g ·kg-1 ·d-1

equal to 76.2 times of human adult’s clinical dose per day. Compared with the control group

mice in Ginseng Tonic Decoction in high dosage group

moderate dosage group and positive control group could prolong the falling time that mice drop from rotating bar because of fatigue;Ginseng Tonic Decoction in high dosage group could prolong the asthmatic time after decapitation and the death time under ambient pressure in mice; Decoction in high dosage group

moderate dosage group and positive control group could prolong the death time under high temperature of 45 ℃ and under low temperature of -5 ℃

there were significant differences(P<0.05 or P<0.01). Conclusion: Tonic Decoction can improve the ability of anti-fatigue

anti-hypoxia and resistance to high and low-temperature. So

the decoction shows anti-stress effects without detectable acute toxicity.