Chemical Analysis and Observation on Vascular Activity of Essential Oil from , Conioselinum tataricum and

ZHANG Ying-chun; CHEN Chang; LI Shao-jing; XU Hai-yu; LI De-feng; WU Hong-wei; YANG Hong-jun

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Chemical Analysis and Observation on Vascular Activity of Essential Oil from , Conioselinum tataricum and

更新时间：2024-01-04

- Chemical Analysis and Observation on Vascular Activity of Essential Oil from , Conioselinum tataricum and
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 14, Pages: 159-165(2011)
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- Published：2011
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ZHANG Ying-chun, CHEN Chang, LI Shao-jing, et al. Chemical Analysis and Observation on Vascular Activity of Essential Oil from , Conioselinum tataricum and [J]. Chinese journal of experimental traditional medical formulae, 2011, 17(14): 159-165.
DOI：

ZHANG Ying-chun, CHEN Chang, LI Shao-jing, et al. Chemical Analysis and Observation on Vascular Activity of Essential Oil from , Conioselinum tataricum and [J]. Chinese journal of experimental traditional medical formulae, 2011, 17(14): 159-165. DOI：

摘要

目的: 分析比较藁本、辽藁本及代用品新疆藁本共7个样品中挥发油的化学成分

并观察对离体血管的舒张活性。方法 :采用水蒸气蒸馏法提取7个藁本样品的挥发油

运用气相色谱-质谱法(GC-MS)对其化学成分进行分析鉴定

并用面积归一化法计算各成分相对含量;离体血管实验观察不同品种藁本挥发油对KCl预收缩大鼠胸主动脉环张力的影响。结果 :从7个藁本样品中共鉴定出82个成分

其中含共有成分14个

各样品所鉴定成分平均占其总挥发油的94%。离体血管实验显示

各样品挥发油对大鼠胸主动脉环均有不同程度的舒张作用

且量效曲线呈非线性关系;半数有效量(ED50)30.4~400.1 μg ·mL-1。结论 :不同品种藁本挥发油化学成分的种类及含量差异显著

对大鼠离体血管的舒张活性明显不同。

Abstract

Objective: To analyze and compare composition and content of volatile oils extracted from seven samples of Ligusticum sinensis

Conioselinum tataricum and Ligusticum jeholense and observe the vascular activity of them in vitro. Method : Seven samples were collected from different producing areas.Hydrodistillation was used for the preparation of volatile oils

and was performed according to the method described in the China Pharmacopoeia (2010).The volatile oils of the seven samples were bioassayed by using KCl-induced aorta contraction assay in vitro as well as chemically analyzed by using GC-MS analysis methods

the components were quantitatively determined with normalization method. Result : eighty-two constituents from volatile oils in total were selected by GC-MS

which occupied more than 94% of included samples in average

including fourteen Common components. Moreover

the research of in vitro vaso-relaxant effect indicated that the volatile oils of all samples possessed vaso-relaxing properties with different effectiveness. and the dose-response curves were all nonlinear

its median effective dose (ED50) were in the range of 30.4-400.1 μg ·mL-1. Conclusion : Chemical constituents and the amounts of these compounds of volatile oils are varied obviously according to different samples

The vasorelaxing effectiveness is also obviously dissimilar.

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Related Author

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Related Institution

State Key Laboratory of Southwestern Chinese Medicine Resources， Chengdu University of Traditional Chinese Medicine

Basic Medical College， Heilongjiang University of Chinese Medicine

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