Determination of Effective Part of Anti-tumor Activity in (Kom.)Nakai f. Rubroaurantiacum Kitag
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Determination of Effective Part of Anti-tumor Activity in (Kom.)Nakai f. Rubroaurantiacum Kitag
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 10, Pages: 193-195(2011)
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Published:2011
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LING Yong, SUN Yong-hui, ZHAO Qin, et al. Determination of Effective Part of Anti-tumor Activity in (Kom.)Nakai f. Rubroaurantiacum Kitag[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(10): 193-195.
DOI:
LING Yong, SUN Yong-hui, ZHAO Qin, et al. Determination of Effective Part of Anti-tumor Activity in (Kom.)Nakai f. Rubroaurantiacum Kitag[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(10): 193-195.DOI:
Determination of Effective Part of Anti-tumor Activity in (Kom.)Nakai f. Rubroaurantiacum Kitag
Objective: ascertain the effective part of anti-tumor activity in Viscum coloratum (Kom.)Nakai f. Rubroaurantiacum Kitag(VCR). Method :We made sarcoma S180 mice as the animal model
the inhibition rate of tumor was used as investigation index. We carried out the screen assay of the anti-tumor for different solvent extraction part of the VCR extracts by 75% alcohol
including petroleum extraction part
chloroform extraction part
acetate extraction part
n-butanol extraction part and the rest. We randomly divided mice with inoculated tumor into 7 groups according to tumor size. The positive control group of mice were given ip cyclophosphamide of 100 mg ·kg-1
the other experimental group at the same time were given ig of 14.2 g ·kg-1 ·d-1 and the blank control group were given the same volume of the blank solvent
continuously administrated for 8 days. Result: The results showed that the extraction of VCR could obviously prevent the growing of the tumor in mice. The inhibition rate of tumor for the chloroform extraction part was 48.8%;the rate of the n-butanol extraction part was 44.1%. Conclusion: The chloroform extraction part and the n-butanol extraction part are the effective part of anti-tumor from VCR.