Morphologic Effect of Tangshenqing on Kidney of Rats with Diabetic Nephropathy
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Morphologic Effect of Tangshenqing on Kidney of Rats with Diabetic Nephropathy
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 14, Pages: 156-159(2011)
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Published:2011
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GAO Shuang-rong, SUN Cui-ying, ZHENG Yan-fei, et al. Morphologic Effect of Tangshenqing on Kidney of Rats with Diabetic Nephropathy[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(14): 156-159.
DOI:
GAO Shuang-rong, SUN Cui-ying, ZHENG Yan-fei, et al. Morphologic Effect of Tangshenqing on Kidney of Rats with Diabetic Nephropathy[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(14): 156-159.DOI:
Morphologic Effect of Tangshenqing on Kidney of Rats with Diabetic Nephropathy
Objective: To investigate morphologic effect of Tangshenqing on kidney of rats with diabetic nephropathy. Method :SD rats were induced diabetic nephropathy by STZ then randomly divided into normal control group
the model group
the positive group
the high dose of Tangshenqing group
the medium dose of Tangshenqing group and the low dose of the group. They were 187
93.5 and 46.75 mg ·kg-1 respectively. After twelve weeks' oral drug administration
the rats were killed and the kidneys were harvested for hematoxylin and eosin and the periodic acid-sliver dyeing. The renal lesions were classified and scored under light microscope. The relative area of mesangium matrix was measured under the periodic acid-sliver dyeing. Result :The renal lesions of the high dose of Tangshenqing group was lightened than the model group. Mesangium matrix relative area of the high dose of Tangshenqing was obviously reduced than the model group (P<0.05). Conclusion :Tangshenqing may relive the extent of mesangium matrix hyperplasia for rats with diabetic nephropathy.
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