Effects of Three-clearing Hypoglycemic Formula on Blood Glucose and Blood Lipid in Experimental Rats with Type 2 Diabetes

WU Fan-wu; WANG Xue; LI Ji-an; LIU Zhi-xia; ZHAO Cui

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Effects of Three-clearing Hypoglycemic Formula on Blood Glucose and Blood Lipid in Experimental Rats with Type 2 Diabetes

更新时间：2024-01-04

- Effects of Three-clearing Hypoglycemic Formula on Blood Glucose and Blood Lipid in Experimental Rats with Type 2 Diabetes
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 8, Pages: 164-167(2011)
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- Published：2011
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WU Fan-wu, WANG Xue, LI Ji-an, et al. Effects of Three-clearing Hypoglycemic Formula on Blood Glucose and Blood Lipid in Experimental Rats with Type 2 Diabetes[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(8): 164-167.
DOI：

WU Fan-wu, WANG Xue, LI Ji-an, et al. Effects of Three-clearing Hypoglycemic Formula on Blood Glucose and Blood Lipid in Experimental Rats with Type 2 Diabetes[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(8): 164-167. DOI：

摘要

目的: 研究三清降糖方对2型糖尿病大鼠血糖和血脂的影响。方法: 雄性Wistar大鼠82只

随机选出10只做为正常对照组(C组)

其余72只大鼠高糖高脂饮食喂养4周后

以小剂量链脲佐菌素2次ip的方法诱发大鼠2型糖尿病模型

以空腹血糖为依据

采用区组随机的方法

分为三清高、中、低剂量组(SG

SD组)、模型对照组(M组)、阿卡波糖组(A组)、罗格列酮组(L组)6组

三清高、中、低剂量组按8.05

4.03

1.61 g ·kg-1分别ig三清降糖方水提物

M组ig生理盐水

A组、L组分别ig等效剂量的阿卡波糖和罗格列酮

共4周

分别在ig前、ig后2周、4周测空腹血糖及餐后2 h血糖

ig 4周后主动脉采血测血脂、肝肾功能

观察比较各组间血糖血脂的变化。结果: ①ig 4周后

SD组空腹血糖水平为(5.0±3.2) mmol ·L-1与M组可见统计学显著差异(P<0.05);②ig 4周后

SD组餐后2 h血糖水平为(9.8±3.3) mmol ·L-1与SG

L组可见统计学显著差异(P<0.05);③ig后4周

各组间高密度脂蛋白(HDL-c)

低密度脂蛋白(LDL-c)

丙氨酸转氨酶(ALT)

天冬氨酸转氨酶(AST)

肌酐(Cr)水平未见统计学显著差异

SZ组、SD组、M组总胆固醇(CHO)甘油三酯(TG)水平低于C组

有统计学显著差异(P<0.05)

但与模型组比较无统计学意义。C组与其他组的血尿素氮(BUN)水平比较可见统计学显著差异(P<0.05)

但各给药组与模型组比无显著差异。结论: 三清降糖复方低剂量应用有较好的降低空腹血糖和餐后2 h血糖效果。

Abstract

Objective: To investigate the effect of the Three-clearing Hypoglycemic Formula(Sanqing Jiangtang Fang) on the blood glucose and blood lipids in type 2 diabetic rats. Method: Ten rats were selected randomly from 82 male Wistar rats to form the normal group(group C). With high fat forage diet of four weeks

the rest 72 rats were injected of small dose of streptozotocin(STZ) intraperitioneally twice to establish rats model with type 2 diabetes. Based on fasting blood sugar levels

the model rats were randomly divided into group treated with high dose of Three-clearing Hypoglycemic Formula(group SG)

group treated with middle dose of Three-clearing Hypoglycemic Formula(group SZ)

group treated with low dose of Three-clearing Hypoglycemic Formula(group SD)

model control group(group M)

group treated with acarbose(group A) and group treated with rosiglitazone(group L). Group SG

group SZ and group SD were administrated with water extracts of Three-clearing Hypoglycemic Formula respectively. Group M was administrated with normal saline. Group A was administrated with acarbose. Compared with group A

group L was administrated with equivalent dosage of rosiglitazone. The sugar tolerances were measured 2 weeks and 4 weeks before and after treatment respectively. Four weeks after treatment

blood was obtained from aorta of rats. blood lipid and hepatic/renal function were tested for further comparisons. Result: ① Four weeks after medicine treatment

there was significant difference between group SD and group M regarding fasting blood glucose levels(P=0.011); ② Four weeks after medicine treatment

there was significant difference in SD group regarding 2 hours-postprandial glucose levels

compared with group SG

group M

group A and group L(P<0.05); ③ Four weeks after medicine treatment

there were no significant difference between each group regarding HDL-c

LDL-c

ALT

AST and crestine levels. Comparing group SZ

group SD

group M and group C

there was significant statistics regarding CHO level(P<0.05). Comparing group SZ

group SD

group A and group C

there was significant difference regarding TG level(P<0.05). Comparing group C with other groups

there was significant difference regarding BUN level(P<0.05). Conclusion: Low dose of Three-clearing Hypoglycemic Formula has better hypoglycemic effect regarding fasting blood glucose and 2 hours-postprandial glucose.

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