Effects of Oils in Hance on Serum Motilin,Somatostatin, Substance P,Vasoactive Intestinal Peptide in Gastrelcosis Mice Model
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Effects of Oils in Hance on Serum Motilin,Somatostatin, Substance P,Vasoactive Intestinal Peptide in Gastrelcosis Mice Model
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 4, Pages: 105-107(2011)
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Published:2011
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WANG Hai-yan, LIU Ya-ming, LI Hai-yan, et al. Effects of Oils in Hance on Serum Motilin,Somatostatin, Substance P,Vasoactive Intestinal Peptide in Gastrelcosis Mice Model[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(4): 105-107.
DOI:
WANG Hai-yan, LIU Ya-ming, LI Hai-yan, et al. Effects of Oils in Hance on Serum Motilin,Somatostatin, Substance P,Vasoactive Intestinal Peptide in Gastrelcosis Mice Model[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(4): 105-107.DOI:
Effects of Oils in Hance on Serum Motilin,Somatostatin, Substance P,Vasoactive Intestinal Peptide in Gastrelcosis Mice Model
摘要
目的 :观察高良姜油对胃溃疡小鼠模型血清胃肠激素的影响。 方法 :ICR小鼠随机分成7组:正常对照组、模型组、良附丸组(2 g ·kg-1)、消旋山莨菪碱片组(0.005 g ·kg-1)、高良姜油低、中、高剂量组(2
4
8 mL ·kg-1)。预防给药6 d后
采用利血平致胃溃疡小鼠模型
ELISA酶联免疫法测定小鼠血清胃动素(MOT)、生长抑素(SS)、P物质(SP)、血管活性肠肽(VIP) 的含量。 结果 :与模型组相比:①各治疗组均能降低利血平致胃溃疡小鼠模型溃疡指数及提高溃疡抑制率( P <0.01)。②高良姜油高、中剂量组
良附丸组、消旋山莨菪碱片组均能降低胃溃疡小鼠模型血清MOT
SP含量 ( P <0.01
P <0.05)
升高血清SS含量 ( P <0.01
PP<0.01)
但中剂量组血清 VIP含量变化无统计学意义。 结论 :高良姜油抗溃疡作用可能与其降低血清MOT
SP的含量
升高血清SS
VIP的含量有关。
Abstract
Objective: To observe effects of oils in Alpinia officinarum Hance(OAOH) on serum gastrointestinal hormones in gastrelcosis mice model. Method: ICR mice were randomly divided into 7 groups:control group
model group
liangfu pills group (2 g ·kg-1)racanisodimine group(0.005 g ·kg-1)
OAOH low dose group
OAOH middle dose group
OAOH high dose group(2
4
8 mL ·kg-1).The gastrelcosis mice model was induced by reserpine
which was then given drugs for 6 days.The content of motilin(MOT)
somatostatin(SS)
substance P(SP)
vasoactive in testinal peptide(VIP) in serum were determined by ELISA. Result: Compared with the model group:① All the treatment decreased ulcer index and increased ulcer inhibition rate(P<0.01).②OAOH
liangfu pills
group racanisodimine obviously decreased MOT
SP in serum(P<0.01
P<0.05)
significantly increased SS in serum (P<0.01
P<0.05);High dose OAOH increased VIP content in serum(P<0.01). Conclusion: OAOH treats gastrelcosis by reducing the content of MOT and SP
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WANG Hai-yan1
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