Study on absorption of Notoginsenoside R1 using rat non-everted gut sac

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Study on absorption of Notoginsenoside R1 using rat non-everted gut sac

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- Study on absorption of Notoginsenoside R1 using rat non-everted gut sac
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 11, (2011)
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- Published：2011
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DengZhenTing. Study on absorption of Notoginsenoside R1 using rat non-everted gut sac[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(11).
DOI：

DengZhenTing. Study on absorption of Notoginsenoside R1 using rat non-everted gut sac[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(11). DOI：

摘要

目的通过不翻转小肠囊法研究药物浓度、能量以及小肠上皮组织的P-蛋白对三七皂苷R1吸收的影响。方法在小肠囊中加入相同浓度的三七皂苷R1溶液，比较不同浓度的三七皂苷R1的吸收差异；加入代谢抑制剂2-硝基酚，观察三七皂苷R1的吸收是否需要能量；观察P-蛋白抑制剂维拉帕米对三七皂苷R1吸收的影响。结果三七皂苷R1的吸收与浓度呈线性，且需要能量。维拉帕米对三七皂苷R1的吸收无显著影响。结论三七皂苷R1在大鼠肠道内的吸收有被动扩散性，三七皂苷R1可能不是P-蛋白的底物。

Abstract

Objective To study the absorption characteristics of Notoginsenoside R1 influenced by density

energy and p-glycoprotein with rat non-everted gut sac system. Methods Different concentration of Notoginsenoside R1 was immersed into Rat non-everted gut sac

and the absorption difference was compared. 2-nitropenol

a metabolic inhibitor

was used to study the influence of energy on the absorption of Notoginsenoside R1. Verapamil

a p-glycoprotein inhibitor

was used to study the influence of p-glycoprotein on the absorption of Notoginsenoside R1. Results The Notoginsenoside R1 concentration in the sac was increasing according to the time. It is obvious that 2-nitropenol affect the absorption of Notoginsenoside R1. Verapamil had no effect on the absorption of Notoginsenoside R1 in sac system. Conclusion The absorption mechanism of Notoginsenoside R1 might be passive diffusion. Notoginsenoside R1 might not be the substrate of p-glycoprotein.

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Related Institution

Experimental Research Center, Anhui Province Key Laboratory of Chinese Medicinal Formula, Anhui University of Chinese Medicine

The First Affiliated Hospital of Anhui University of Chinese Medicine

Guangdong Pharmaceutical University

Sun Yat-sen University

Guangdong Institute of Traditional Chinese Medicine

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