Objective: To study the pharmacological effects of Coptidis Rhizoma and Caryophylli Flos on anti-inflammatory

analgesic and for treatment of oral ulcers with external use. Method: In the anti-inflammatory experiments 60 rats were randomly divided into 5 groups.Their right feet plantar were intradermally injected with 1% carrageenan and given Coptidis Rhizoma extract externally

the paw circumference was measured with soft rule.In analgesia experiments

60 mice were randomly divided into 5 groups.Their tails were given Caryophylli Flos extract externally

tail tenderness threshold was measured with tenderness instrument.In the oral ulcer experiment

96 rats were randomly divided into 8 groups.After the model of oral ulcers

the rats were given Coptidis Rhizoma or Caryophylli Flos extract externally

the ulcer healing rate was then evaluated with computer calculating. Result: ① The anti-inflammatory experiments showed that berberine inhibited topical carrageenan induced rat paw edema

there was significant difference between the dose group and control group(P<0.05).② Analgesic experiments showed that clove \ could significantly elevate the tenderness mechanical pain threshold.there was significant difference between the large

medium dose groups and control group(P<0.05).③ Experiments showed that treatment of oral ulcers induced by phenol with berberine and Caryophylli Flos could gain significant effect

there was significant difference between the large

medium dose groups and control group(P<0.05);also there was significant difference between the medium dose berberine group and the medium dose Caryophylli Flos group (P<0.05)

the effect of Caryophylli Flos was better. Conclusion: External use of Coptidis Rhizoma extract has significant anti-inflammatory effects.External use of Caryophylli Flos extract shows effect of analgesia.External use of Coptidis Rhizoma and Caryophylli Flos together can treat oral ulcers effectively.