Study on Tarnsdermal Delivery of Paeoniflorin by Cutaneous Microdialysis in Rat

CAI Yu; LIU Xin-yan; LIANG Wen-ge

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Study on Tarnsdermal Delivery of Paeoniflorin by Cutaneous Microdialysis in Rat

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- Study on Tarnsdermal Delivery of Paeoniflorin by Cutaneous Microdialysis in Rat
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 10, Pages: 116-118(2011)
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- Published：2011
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CAI Yu, LIU Xin-yan, LIANG Wen-ge. Study on Tarnsdermal Delivery of Paeoniflorin by Cutaneous Microdialysis in Rat[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(10): 116-118.
DOI：

CAI Yu, LIU Xin-yan, LIANG Wen-ge. Study on Tarnsdermal Delivery of Paeoniflorin by Cutaneous Microdialysis in Rat[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(10): 116-118. DOI：

摘要

目的: 研究芍药苷的经皮渗透性

并考察透皮渗透促进剂氮酮(azone)对经皮渗透性的影响。方法: 以Wistar大鼠为实验动物

采用经皮微渗析技术进行经皮渗透性研究。以浓差法测定探针的体外回收率

以反向渗析法测定探针的在体回收率。结果: 氮酮可以显著提高药物透过性

5% azone经皮传递率分别为0.906 9

1.887 8

1.272 8 μg ·h-1。结论: azone是芍药苷经皮吸收优良的渗透促进剂

且促渗效果与浓度不成线性。经皮微渗析技术是在体研究药物经皮渗透性的有效手段。

Abstract

Objective: To study the permeability of paeoniflorin with enhancer azone. Method :Wistar rats as experimental animal models

cutaneous microdialysis technique was used in penetration studies. The in vitro recovery of the probe was assessed by concentration difference method and in vivo recovery was estimated by retrodialysis method. Result: Azone could significantly increase drug permeability

with 1%

3% and 5% azone transdermal delivery was 0.906 9

1.887 8 and 1.272 8 μg ·h-1. Conclusion: Azone is an excellent enhancers for cutaneous absorption of paeoniflorin

and the penetration effect and the concentration will not be linear. The cutaneous microdialysis is a effective method for in vivo cutaneous penetration study.

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Related Institution

Henan University of Chinese Medicine

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School of Clinical Medicine，Changchun University of Chinese Medicine

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