Objective: To reveal the mechanism of the protection of Dusuqing Granule through the levels of the inflammatory factor expression in multiple organ injury caused by Klebsiella pneumonia. Method : Fifty-five male Sprague Dawley (SD) aged rats were randomlLy divided into control group (CG)

model group (MG)

Dusuqing group (DG) and Lomefloxacin group (LG). There were 25 rats in the model group and 10 in each of the other three groups. The models of multiple organ injury caused by pneumonia were made by injection of Klebsiella pneumoniae through the tracheal intubation. The expressions of inflammatory factors like tumor necrosis factor-α(TNF-α)

interleukin-1(IL-1) and interleukin-6(IL-6) in the lungs

the theart

the kidney and the small intestine were measured. Result: The level of expressions of TNF-α

IL-1 and IL-6 in the lungs

the hear

the kedney and the small intestine in MG were significantly higher than those in CG (P<0.01 or P<0.05). The neutrophil rates and the counts of WBC in peripheral blood increased dramatictly in MG (P<0.01). The pathological changes under light microscope were obvious in the organs in MG (P<0.01 or P<0.05). Compared with MG

the levels of expressions of TNF-α

IL-1

and IL-6 in the lungs

the heart

the kidney and the small intestine in DG decreased significantly (P<0.01 or P<0.05). The neutrophil rates and the counts of WBC in peripheral blood dropped dramaticly in DG (P<0.01). The pathological injuries were light obviously in the organs in DG (P<0.01 or P<0.05). Conclusion: Low the levels of inflammatory factor expression

such as TNF-α

IL-1 and IL-6

so as to reduce organ damage

which might be one of the mechanisms of Dusuqing Granule’s protection in multiple organ injury.