Effect of Effective Fraction of Xianglian Pill on Acute Ulcerative Colitis in Mice
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Effect of Effective Fraction of Xianglian Pill on Acute Ulcerative Colitis in Mice
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 12, Pages: 170-173(2011)
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Published:2011
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ZHANG Wen-xin, TAN Xiao-mei, HU Yuan-li, et al. Effect of Effective Fraction of Xianglian Pill on Acute Ulcerative Colitis in Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(12): 170-173.
DOI:
ZHANG Wen-xin, TAN Xiao-mei, HU Yuan-li, et al. Effect of Effective Fraction of Xianglian Pill on Acute Ulcerative Colitis in Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(12): 170-173.DOI:
Effect of Effective Fraction of Xianglian Pill on Acute Ulcerative Colitis in Mice
Objective: To investigate the therapeutic effects of effective fraction of Xianglian Pill on acute ulcerative colitis (UC) induced by dextran sulfate sodium (DSS) and 20% alcohol in mice. Method: Acute ulcerative colitis was induced by DSS and 20% alcohol
and effective fractions of Xianglian Pill were given by stomach for 7 days at the same time. The genera situations and histopathological changes were observed during the experiment disease activity index (DAI) and colon length
intestinal weight index
spleen weight and The levels of serum MDA were evaluated. Result: Effective fraction of Xianglian Pill greatly ameliorated the symptom of UC and histopathological changes as compared with UC control. The levels of serum MDA were obviously reduced. Conclusion: Effective fraction of Xianglian Pill is much helpful to the colitis mouse induced by DDS and 20% alcohol.
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