Objective: To observe the hypoglycemic effect of the Astragalus Hypoglycemic Granule on type 2 diabetic mice caused by streptozotocin(STZ). Method: Eighty SPF male C57BL/6 mice of 4-5 weeks old were given the diet of maintenance fodder for one week. After that 10 mice were selected randomly to form the normal group. Given high fat forage diet and intraperitoneal injection of STZ of 60 mg ·kg-1

type 2 diabetic model was established for the other 60 mice. Then

they were randomly divided into low dose of Astragalus Hypoglycemic Granule group(1.0 g ·kg-1)

middle dose of Astragalus Hypoglycemic Granule group(2.0 g ·kg-1)

high dose of Astragalus Hypoglycemic Granule group(3.0 g ·kg-1)

metformin hydrochloride group(0.3 g ·kg-1)

Ginseng-Astragalus Hypoglycemic Granule group(0.2 g ·kg-1)

and model control group(n=10 in each group). The mice in normal and model control groups were given distilled water once a day and the ones in other groups were administrated medicine treatment by ig once a day for 14 days. The changes regarding fasting blood glucose(FBG)

body weight

serum insulin and pathological changes in β-Islet-cells were observed after continuous 14 days’ medical administration of Astragalus Hypoglycemic Granule. Result: FBG was decreased significantly

the content of serum insulin was increased obviously

the body weight was controlled effectively and the damage of β-Islet-cells was repaired in type 2 diabetic mice of each group after medicine administration. Compared with the mice in model control group ·L-1

serum insulin:(9.69±2.66) mU ·L-1

weight:(20.00±1.18)g]

there were significant difference with the mice in high dose of Astragalus Hypoglycemic Granule group ·L-1

serum insulin:(18.98±1.41) mU ·L-1

weight:(26.08±0.63)g] and the mice in metformin hydrochloride group ·L-1

serum insulin:(17.33±1. 23) mU ·L-1

weight:(25.83±0.89)g](P<0.01). There showed statistical significance in the mice of low dose of Astragalus Hypoglycemic Granule group ·L-1

serum insulin:(15.89±1.38)mU ·L-1

weight:(25.69±0.44) g] and the mice in Ginseng-Astragalus Hypoglycemic Granule group ·L-1

serum insulin:(15.80±1.21) mU ·L-1

weight:(22.90±0.74) g](P<0.05). Conclusion: Astragalus Hypoglycemic Granule can significantly decrease fast blood glucose

increase the content of serum insulin and has repair function for β-islet-cells.