Objective: To study the influence of Ginseng Two-ingredient Capsule on blood glucose and blood lipids in the diabetic rats. Method: Sixty SPF male Wistar rats with the weight of (180±20) g were given normal forage adaptively for 7 days. Ten rats were selected randomly to form normal group. With high fat forage diet of four weeks

the rest 50 rats were injected with 30 mg ·kg-1 of STZ intraperitioneally to establish rat model of diabetes. The model rats were randomly divided into model control group with 10 rats

Ginseng Two-ingredient Capsule group with 10 rats ig given the capsule

metformin hydrochloride group with 10 rats served metformin hydrochloride by way of ig

and Ginseng-Astragalus Hypoglycemic Granule group with 10 rats treated with Ginseng-Astragalus Hypoglycemic Granule by way of ig for 14 days. The fasting blood glucose and weight of the rats were measured before the treatments and after the treatments for two weeks. Blood sample was finally obtained from aorta of rats. Triglyceride and cholesterol were tested to evaluate the influence of Ginseng Two-ingredient Capsule on blood glucose

blood lipids

and the body weight in the diabetic rats was also investigated. Result: Fourteen days later after medicine treatment

Ginseng Two-ingredient Capsule could reduce blood sugar and blood lipids in the type 2 diabetic rats and control weight-reduction for rats effectively which have significant difference compared with that in the model group (P<0.05). Conclusion: Ginseng Two-ingredient Capsule can reduce blood sugar and blood lipids in type 2 diabetic rats and control weight-reduction for the rats effectively. However

its hypoglycemic effect was inferior to that of metformin or Ginseng-Astragalus hypoglycemic Granule.