Objective: To study the effect of the decoction of invigorating spleen and regulating Qi(DISRQ) on gastrointestinal motility

motilin(MTL)

gastrin(GAS) in rats with functional dyspepsia(FD)

exploring the mechanism of the DISRQ for adjusting gastrointestinal dynamics. Method: Seventy-two Wistar rats of SPF class were randomly divided into six groups i.e. normal group

model group

low dose of DISRQ group

middle dose of DISRQ group

high dose of DISRQ group and cispride group(n=12 each

male and female in half). The normal group and model group were given physiological saline intragastrically; while DISRQ groups were administrated with DISRQ at doses of 80

48

16 g ·kg-1 respectively

and cisapride group was given cisapride of 0.005 g ·kg-1. Investigation started from 7 days after modeling and continued for 14 successive days. Gastrointestinal Motility

MTL and GAS in each group were observed. Result: Different doses of DISRQ could improve the function of gastric emptying and promote intestinal propulsion of FD rats in different extent(P<0.05 or 0.01)

and the effect of the high dosage showed no significant difference with those in the positive control group(cispride).Compared with those in normal group

the level of plasma MLT and GAS in the model group were remarkably decreased(P<0.05). Different doses of DISRQ could increase the content of MLT and GAS in different extent(P<0.05). There was no significant difference between high dose group of DISRQ and the cisapride group. Conclusion: The therapeutic effect of DISRQ in experimental FD rats might result from improving gastric emptying

promoting the small bowel peristalsis

enhancing the level of plasma MTL and GAS.