Objective: To study the protection of Ruyi Dingchuan pill on emphysema rat

and provides theoretical basis for its clinical application. Method: Sixty SD rats were randomly divided into normal group

model group

Ruyi Dingchuan pill of high

medium and low dose groups

Guilong Kechuanning capsule control group.Rat model of emphysema was established by intratracheal instillation of lipopolysaccharide (LPS) twice and exposed to cigarette smoke daily.After 3 weeks

the rats were administrated by gastric lavage of corresponding drugs for 14 days.Artery blood gas analysis and pathological changes in the lungs were observed.The expression of IL-10 and TNF-α was examined by ELISA. Result: Pathological changes with obvious emphysema and inflammation cell infiltrates were found after modeling.Average alveolar area and the levels of TNF-α in the model group were higher than those in the normal group(P<0.05).The arterial oxygen content and the levels of IL-10 in the model group were lower than those in the normal group(P<0.05).Ruyi Dingchuan pill could obviously lessen the infiltrations of inflammatory cells and formation of emphysema

increase arterial oxygen content

and significantly reduce the expression of TNF-α (119.80±5.53) ng ·L-1 and increase the expression of IL-10 (33.59±7.92) ng ·L-1 in the blood serum(P<0.05).Its effect was statistically insignificant compared with the positive drug. Conclusion: Ruyi Dingchuan pill had apparent protective effect for emphysema rats.