Effect of Fructus Bruceae Oil Emulsion Combined with Chemotherapy of GP Regimen on Immune Function in Patients with Advanced NSCLC
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Effect of Fructus Bruceae Oil Emulsion Combined with Chemotherapy of GP Regimen on Immune Function in Patients with Advanced NSCLC
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 11, Pages: 254-256(2011)
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Published:2011
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ZHANG Yu, YU Li-ke, XIA Ning. Effect of Fructus Bruceae Oil Emulsion Combined with Chemotherapy of GP Regimen on Immune Function in Patients with Advanced NSCLC[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(11): 254-256.
DOI:
ZHANG Yu, YU Li-ke, XIA Ning. Effect of Fructus Bruceae Oil Emulsion Combined with Chemotherapy of GP Regimen on Immune Function in Patients with Advanced NSCLC[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(11): 254-256.DOI:
Effect of Fructus Bruceae Oil Emulsion Combined with Chemotherapy of GP Regimen on Immune Function in Patients with Advanced NSCLC
Objective: To observe the effect of Fructus Bruceae oil emulsion (FBE) combined with chemotherapy on immune function in patients with advanced non-small-cell lung cancer (NSCLC). Method: One hundred and fifty-six patients with advanced NSCLC were randomly assigned to two groups
the 74 patients in the control group were only treated with chemotherapy of GP regimen
84 in the treatment group with the chemotherapy of the same regimen and combined with FBE.The cellular immune(CD3+
CD4+
CD8+
CD16+ CD56+)and humoral immunity(IgG
IgA
IgM
C3
C4)were tested by immunocytochemistry method and biochemistry method respectively.The treatment effects on immune were compared between before and after chemotherapy. Result: The response rates were 40.3% in the treatment group and 36.5% in the control group
there was no statistical difference between them.Compare before chemotherapy
the cellular immune function in the control group was decreased
which was increased in the treatment group.The cellular immune function in the treatment group was better than that in the control group after chemotherapy(P<0.05 or P<0.01).No visible change in humoral immune was found in each group. Conclusion: FBE combined with chemotherapy of GP regimen can improve the cellular immune function in patients with advanced NSCLC.
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