Effect of Tangzhipiing Granules on Nitric Oxide, Nitric Oxide Synthase and Morphological Changes in Kidney in Rats with Diabetic Nenopathy

LI Chang-xin; XIE Dong-xia; HUANG Xian-zhang

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Effect of Tangzhipiing Granules on Nitric Oxide, Nitric Oxide Synthase and Morphological Changes in Kidney in Rats with Diabetic Nenopathy

更新时间：2024-01-04

- Effect of Tangzhipiing Granules on Nitric Oxide, Nitric Oxide Synthase and Morphological Changes in Kidney in Rats with Diabetic Nenopathy
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 11, Pages: 182-184(2011)
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- Published：2011
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LI Chang-xin, XIE Dong-xia, HUANG Xian-zhang. Effect of Tangzhipiing Granules on Nitric Oxide, Nitric Oxide Synthase and Morphological Changes in Kidney in Rats with Diabetic Nenopathy[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(11): 182-184.
DOI：

LI Chang-xin, XIE Dong-xia, HUANG Xian-zhang. Effect of Tangzhipiing Granules on Nitric Oxide, Nitric Oxide Synthase and Morphological Changes in Kidney in Rats with Diabetic Nenopathy[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(11): 182-184. DOI：

摘要

目的: 通过观察糖脂平颗粒对糖尿病肾病大鼠肾组织一氧化氮(NO)、一氧化氮合酶(NOS)水平的影响。探讨糖脂平颗粒对糖尿病肾病大鼠肾脏的保护作用。方法: Wistar大鼠60只

雌雄各半

采用高脂饲料加小剂量(40 mg ·kg-1)ip链脲佐菌素(STZ)造模

按体重编号

以随机数字表法分为4组:模型组、糖脉康颗粒组、糖脂平颗粒高、低剂量组

分别给与生理盐水、糖脉康颗粒、糖脂平颗粒进行干预

测定干预后各组大鼠肾组织匀浆NO和NOS

制备肾组织切片

观察肾组织形态学改变。结果: 治疗后各治疗组NO为(37.24±4.16)~(44.74±6.08) μmol ·g-1与模型组(30.47±8.33)μmol ·g-1比较升高

NOS各治疗组为(0.44±0.13)~(0.61±0.17)U ·mg-1与模型组(0.27±0.14)U ·mg-1比较亦升高

均有显著性差异(P<0.05)

糖脂平颗粒小剂量组与糖脉康颗粒组比较

指标均没有显著性差异;而糖脂平颗粒大剂量组与糖脉康颗粒组比较

NO及NOS均有显著性差异糖脂平颗粒高剂量组治疗效果优于低剂量组和糖脉康颗粒组。肾组织切片显示:糖脂平颗粒2个高、低剂量组和糖脉康颗粒组肾脏组织均有不同程度的修复

糖脂平颗粒高剂量组优于其他各给药组。结论: 糖脂平颗粒可升高糖尿病肾病大鼠肾组织匀浆一氧化氮及NOS

同时促进肾脏受损组织的修复

对糖尿病肾脏具有保护作用

Abstract

Objective: To observe the effect of Tangzhiping granules on NO

NOS and morphological changes of kidney tissue in diabetes mellitus (DM) Wistar rats with nenopathy. Method: The diabetic nenopathy model of rats with was successfully made by high adipose diet and injection of streptozocin (STZ) in abdominal cavity.Then the rats were intervened withTangmaikang granules and Tangzhiping granules and the contents of NO and NOS were detected.The morphological changes in kidney tissue wereobserved. Result: After treatment

and the contents of NO and NOS in kidney in the treatment groups were increased significantly compared with that of the model (P<0.05)

The contents of NO and NOS in the Tangzhiping high dose group were increased significantly compared with those in the positive drug group and in the Tangzhiping low dose group (P<0.05).Morphological slides showed that the Tangzhiping high and low doses and the positive control drug had protective effect on injury caused by diabetic nenopathy.The protection come from the Tangzhiping high dose was the most. Conclusion: Tangzhiping granules can increase NO and NOS in rats with diabetic nenopathy and promote the kidney tissue repairs at the same time.

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