Qiaojing Bushen Capsule’s Suppression Action on Kidney Harmin Rat of Diabeles Modele

MA Hui-xia; LIU Yue-juan; LI Jie; HAN Shu-ying

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Qiaojing Bushen Capsule’s Suppression Action on Kidney Harmin Rat of Diabeles Modele

更新时间：2024-01-04

- Qiaojing Bushen Capsule’s Suppression Action on Kidney Harmin Rat of Diabeles Modele
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 12, Pages: 156-158(2011)
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- Published：2011
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MA Hui-xia, LIU Yue-juan, LI Jie, et al. Qiaojing Bushen Capsule’s Suppression Action on Kidney Harmin Rat of Diabeles Modele[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(12): 156-158.
DOI：

MA Hui-xia, LIU Yue-juan, LI Jie, et al. Qiaojing Bushen Capsule’s Suppression Action on Kidney Harmin Rat of Diabeles Modele[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(12): 156-158. DOI：

摘要

目的: 观察荞精补肾胶囊(QJBS)对糖尿病大鼠肾脏损害的影响。方法: 用30 mg ·kg-1链脲佐菌素(STZ)和高脂饲料法诱导建立糖尿病大鼠模型。将SD大鼠随机分为模型对照组、消渴丸组、荞精补肾胶囊高低剂量组

ig给药

每天1次

连续8周

观察各组大鼠24 h尿微量蛋白排泄率

血、尿肌酐和内生肌酐清除率的情况。结果: 与模型组比较

各药物治疗组均能明显降低24 h尿微量蛋白排泄率和血肌酐含量(P<0.01)

而增加尿肌酐排泄量和尿肌酐清除率(P<0.01)。QJBS高剂量组肾小球形态接近正常

肾小管无明显病变

间质炎症亦不明显;QJBS低剂量组间质炎症不明显

但仍有肾小球萎缩病变

肾小管接近正常。结论: QJBS对STZ所致糖尿病大鼠肾脏损害具有一定抑制作用。

Abstract

Objective: To investigate the effects of Qiaojing Bushen capsule(QJBS) on the kidneyharmin rats of diabetes models. Method: Diabetes rats model are established by 30 mg ·kg-1 streptozocin(STZ) and the high fat feed. The SD rats were randomly divided into four groups:model control group

Xiaokewan-treated group

high-doses QJBS group and low-doses group QJBS group. Filling the stomach with the medicine

once a day

continuously 8 weeks

we observed 24 h urinary albumin excretion rate(UAER) excretion rate and the blood and urinates creatinine and the endogenous endogenous percentage clearance in rats of each group. Result: Compared with the model group

medicinal treatment group can reduce 24 hUAER excretion rate obviously and the blood endogenous content

but increases the urine endogenous excretion quantity and the urine endogenous percentage clearance. QJBS and other medicinal groups can improve the kidney pathological change in varying degree. QJBS low dosage group’s function was not remarkable. Conclusion: QJBS could inhibit mice kidney damage induced by STZ of type 2 DM.

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Related Institution

Hebei United University Traditional Chinese Medicine College

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