Anti-inflammatory Effects of Extracts from

ZHANG Jun-zhi; MO Gang; YANG Cheng-fang; LIANG Rong-gan

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Anti-inflammatory Effects of Extracts from

更新时间：2024-01-04

- Anti-inflammatory Effects of Extracts from
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 8, Pages: 204-206(2011)
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- Published：2011
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ZHANG Jun-zhi, MO Gang, YANG Cheng-fang, et al. Anti-inflammatory Effects of Extracts from [J]. Chinese journal of experimental traditional medical formulae, 2011, 17(8): 204-206.
DOI：

ZHANG Jun-zhi, MO Gang, YANG Cheng-fang, et al. Anti-inflammatory Effects of Extracts from [J]. Chinese journal of experimental traditional medical formulae, 2011, 17(8): 204-206. DOI：

摘要

目的: 研究茅莓正丁醇组分的抗炎作用。方法: 选用昆明种小白鼠及SD大白鼠

茅莓正丁醇组分高、低剂量组分别按提取物量1.0

0.5 g ·kg-1 ig给药

共7 d。应用二甲苯和角叉菜胶致炎法分别建立小鼠耳肿胀模型和大鼠足跖肿胀模型。实验分为模型对照组(生理盐水)、阳性对照组(地塞米松)和茅莓正丁醇组分组。计算各组小鼠耳廓炎症肿胀度及抑制率

采用容积测量法观察角叉菜胶所致大鼠足跖肿胀度和肿胀抑制率。结果: 与模型对照组比

茅莓正丁醇组分作用后的小白鼠耳廓肿胀度显著降低(P<0.05)

高、低剂量组肿胀抑制率分别为81.76%

76.79%;明显减轻大鼠足跖肿胀度

差异具有统计学意义(P<0.05)。结论: 茅莓正丁醇组分有明显的抗炎作用。

Abstract

Objective: To study the anti-inflammatory effects of the extract of Rubus parvifolius. Method: Butanol fraction from R. parvifolius was obtained for the experiments. Kunming mice and SD rats were used as the animals

and the selection of two dosages was 1.0

0.5 g ·kg-1 ig for 7 d. Mice ear inflammatory edema was induced with xylene and rat paw edema was created by injection of carrageenan. The mice or rats were divided into groups including negative control (normal saline)

positive control (dexamethasone) and the group of the extract from R. parvifolius. The swelling degree of mice ear and rat paw edema

and the swelling inhibition effect caused by the extract of R. parvifolius were observed by using method of volume measurement. Result: The swelling degree of auricle inflammation in mice was reduced by the extract from R. parvifolius compared with that of the control group (P<0.05)

and the swelling inhibitive rates were 81.76% and 76.79% in high and low dose group respectively. The foot swelling of rats induced by carrageenan was significantly inhibited by the extract as compared with that in the control group (P<0.05). Conclusion: The extract (total saponins) of R. parvifolius has an obvious anti-inflammatory effect.

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