Experimental Research on Effect of Qingpeng Paste Treating Adjuvant Arthritis in Rats

LI Hui-min; LI Bao-li

您当前的位置：

首页 >

文章列表页 >

Experimental Research on Effect of Qingpeng Paste Treating Adjuvant Arthritis in Rats

更新时间：2024-01-04

- Experimental Research on Effect of Qingpeng Paste Treating Adjuvant Arthritis in Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 6, Pages: 228-231(2011)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2011
- 稿件说明：
移动端阅览
LI Hui-min, LI Bao-li. Experimental Research on Effect of Qingpeng Paste Treating Adjuvant Arthritis in Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(6): 228-231.
DOI：

LI Hui-min, LI Bao-li. Experimental Research on Effect of Qingpeng Paste Treating Adjuvant Arthritis in Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(6): 228-231. DOI：

摘要

目的: 探讨外用藏药奇正青鹏软膏局部应用治疗大鼠佐剂性关节炎的作用及特点。方法: 50只大鼠随机抽取10只作为正常组

其余40只注射弗氏完全佐剂造模后分为模型组、青鹏膏高剂量组(1.6 g ·kg-1)、青鹏膏低剂量组(0.4 g ·kg-1)。治疗组根据体重分别按1.6

0.4 g ·kg-1剂量将药物涂抹于右后肢踝关节周围

连续用药4周。观察青鹏软膏不同剂量对佐剂性关节炎大鼠右后肢肿胀率

血清一氧化氮(NO)、白介素-1β(IL-1β)含量的影响

HE染色镜下观察大鼠踝关节滑膜病理改变。结果: 外用藏药青鹏软膏组与模型组比较

大鼠的足肿胀率明显降低(P<0.05)

血清NO水平显著降低(P<0.05)

病理研究表明青鹏软膏有效抑制佐剂性关节炎大鼠关节滑膜损伤程度

但对血清IL-1β水平没有明显影响。结论: 青鹏软膏局部外用对大鼠佐剂性关节炎具有治疗作用。

Abstract

Objective: To study the effect of local application of Qingpeng Paste for treating adjuvant arthritis (AA) in rats. Method: Ten rats was eandomly selected form fifty rats as the normal control

the other rats were used to made the adjuvant arthritis model. The model was induced by injection of Freund’s complete adjuvant. Then

the fourty rats were divided into model group

Qingpeng Paste high dose group (1.6 g ·kg-1) and Qingpeng Paste low dose group (0.4 g ·kg-1). The influence on swelling of the rear leg

the serum nitric oxide (NO) and interleukin-1β(IL-1β) level in the adjuvant arthritis rats were observed. HE staining was used to examine the pathological changes in joint synovium of the rat after using Qingpeng Paste locally. Result: Qingpeng Paste significantly decreased swelling of joints in AA rats compared with the control (P<0.05). the levels of NO of the rats in Qingpeng Paste groups were significantly decreased compared with the control (P<0.05). However

the level of IL-1β did not change. The pathological changes un the synovium tissues were markedly ameliorated in Qingpeng Paste groups. Conclusion: Qingpeng Paste can ameliorate the symptom of adjuvant arthritis in rats.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Experimental Treatment of Rheumatoid Arthritis by Aconiti Lateralis Radix Praeparata

Mechanism of Yiyuan Qiwei Pills in Treatment of Diabetes Mellitus-induced Erectile Dysfunction

Protective Effect of Danggui Buxue Tang on Impaired Functional Activity of Endothelial Cells Exposed to Low Flow Shear Stress

Effect of Exogenous Nitric Oxide on Plant Hormones and Enzyme Content of Acanthopanax senticosus Seeds

Periodic Observation for NO Level and NOS Activity in Serum and Brain Tissue of Rats Damaged by Cerberal lschemic Reperfusion with Naoluotong

Related Author

LIU Jian-lei

Ding WANG

Shaofeng ZHANG

Xue JIANG

Xiang LYU

Taiping ZHU

Jiakun LIN

Zhen QIN

Related Institution

Shijiazhuang Medical College

Baixiang Country Central Hospital

Pingxiang Hospital of Traditional Chinese Medicine

School of Basic Medicine, Guizhou Medical University

School of Extended Education, Guangzhou University of Chinese Medicine

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰