Effect of Anwei Decoction on Intestinal Trefoil Factor mRNA in Chronic Atrophic Gastritis Rats

WEI Wei; LIN Shou-ning; ZHU Yong-ping

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Effect of Anwei Decoction on Intestinal Trefoil Factor mRNA in Chronic Atrophic Gastritis Rats

更新时间：2024-01-04

- Effect of Anwei Decoction on Intestinal Trefoil Factor mRNA in Chronic Atrophic Gastritis Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 3, Pages: 159-162(2011)
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- Published：2011
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WEI Wei, LIN Shou-ning, ZHU Yong-ping. Effect of Anwei Decoction on Intestinal Trefoil Factor mRNA in Chronic Atrophic Gastritis Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(3): 159-162.
DOI：

WEI Wei, LIN Shou-ning, ZHU Yong-ping. Effect of Anwei Decoction on Intestinal Trefoil Factor mRNA in Chronic Atrophic Gastritis Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(3): 159-162. DOI：

摘要

目的: 探讨安胃汤对实验性慢性萎缩性胃炎大鼠模型的肠三叶因子(intestinal trefoil factor

TFF3)基因表达的影响。方法: 采用甲基硝基亚硝基胍(N-methyl-N'-nitro-N-nitroso-guani dine

MNNG)慢性萎缩性胃炎(chronic atrophic gastritis

CAG)大鼠模型

36只清洁级健康雄性Wistar大鼠随机分为病理模型组、安胃汤组、胃复春组共3组。实时荧光定量PCR方法观察安胃汤对实验性慢性萎缩性胃炎大鼠模型胃黏膜TFF3 mRNA表达的影响

对后者进行图像分析及统计学处理。结果: 病理模型组

安胃汤组和胃复春组TFF3 mRNA/β-actin值分别为(0.95±0.23)

(0.43±0.04)

(0.64±0.04)

与病理模型组比较

安胃汤组和胃复春组均显著降低TFF3 mRNA/β-actin值(P<0.01);安胃汤组作用优于胃复春组(P<0.05)。结论: 安胃汤可能通过降低胃黏膜TFF3 mRNA表达而起到治疗CAG作用。

Abstract

Objective: To explore the effect of Anwei decoction on the expression of intestinal trefoil factor mRNAs (TFF3 mRNAs) in chronic atrophic gastritis(CAG) rats. Method: Thirty six rats were randomly divided into three groups: model group

Anwei decoction group and Weifuchun group. CAG was induced by N-methy-N-nit ro-N-nitroguanidine(MNNG). The expression of TFF3 mRNA in rats gastric mucosas was determined by real-time polymerase chain reaction (real-time PCR). Result: The ratio of TFF3 mRNA/β-actin was 0.95±0.23

0.43±0.04

0.64±0.04 respectively in the model group

Anwei decoction group and Weifuchun group. Compared with that in the model group

the expression of TFF3 mRNA was remarkably reduced in Anwei decoction group and Weifuchun group(P<0.01). Anwei decoction showed better effect than Weifuchun(P<0.05). Conclusion: Anwei decoction may treat CAG by reducing the expression of TFF3 mRNA in gastric mucosas.

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Related Institution

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Affiliated Hospital of Shandong University of TCM

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Anhui Province Key Laboratory of Chinese Medicinal Formula

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