Anti-inflammatory and Analgesic Effects of Ligustilide

LIN Qiao; ZHAO Ai-guo; CHEN Jian-nan; LAI Xiao-ping; GUI Shu-hua; FANG Chun-ping

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Anti-inflammatory and Analgesic Effects of Ligustilide

更新时间：2024-01-04

- Anti-inflammatory and Analgesic Effects of Ligustilide
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 11, Pages: 165-168(2011)
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- Published：2011
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LIN Qiao, ZHAO Ai-guo, CHEN Jian-nan, et al. Anti-inflammatory and Analgesic Effects of Ligustilide[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(11): 165-168.
DOI：

LIN Qiao, ZHAO Ai-guo, CHEN Jian-nan, et al. Anti-inflammatory and Analgesic Effects of Ligustilide[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(11): 165-168. DOI：

摘要

目的: 研究藁本内酯的镇痛、抗炎作用。方法: 以昆明种小鼠(18~22 g)和SD大鼠(180~220 g)为试验动物

研究100

20 mg ·kg-1藁本内酯ig给药对受试动物的镇痛和抗炎作用。采用热板法和醋酸致小鼠扭体反应

进行镇痛实验;应用醋酸致小鼠腹腔毛细血管通透性增高、二甲苯致小鼠耳廓肿胀、角叉菜胶致大鼠足跖肿胀及大鼠棉球肉芽肿4种动物模型进行抗炎药效学试验。结果: 藁本内酯3个剂量组均能明显延迟小鼠舔后足时间(P＜0.05或P＜0.01)

并能减少醋酸引起的小鼠扭体反应

镇痛率分别为61.21%

48.12%和43.61%;并且藁本内酯各剂量组对醋酸诱发小鼠腹腔毛血管通透性增高的抑制率分别为64.84%

57.85%和49.67%;对二甲苯诱发的小鼠耳廓肿胀有明显的抑制率分别为52.06%

41.51%和34.21%;对角叉菜胶引起的足跖肿胀

在1~3 h的抑制率在42%以上;而对棉球肉芽增生的抑制率达52.64%

50.32%

45.33%。结论: 藁本内酯具有一定的镇痛作用

对急、慢性炎症均有明显抑制作用。

Abstract

Objective: To evaluate the anti-inflammatory and analgesic effects of ligustilide. Method: The pharmacodynamic effects were observed in 2 analgesic tests and 4 inflammatory models in experimental animals

including:hot plate test in mice

writhing reaction induced by acetic acid in mice

increased permeability of abdominal cavity induced by acetic acid in mice

auricular edema induced by dimethy benzene in mice

paw swelling caused by carrageenan in rats

cotton-pellet granuloma in rats. Result: Ligustilide (100

20 mg ·kg-1) could delay the latency of licking of the hind paw in hot plate test.And it could reduce the times of writhe response actions

and the inhibition rates were 61.21%

48.12%

43.61% accordingly.Ligustilide could distinctively inhibit the increase in permeability of abdominal cavity induced by acetic acid in mice

and the inhibition rates were 64.84%

57.85%

49.67% respectively.Ligustilide could significantly inhibit the auricular edema induced by dimethy benzene

and the inhibition rates were 52.06%

41.51%

34.21%.Ligustilide could significantly inhibit the paw swelling caused by carrageenan in rats

and the inhibition rates were more than 42% from 1 to 3 hour.Ligustilide could significantly inhibit the cotton-pellet granuloma in rats

and the inhibition rates were 52.64%

50.32%

45.33%. Conclusion: Ligustilide has an analgestic effect and can significant inhibit acute and chronic inflammation in animals.

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