Effects of Guben Yishen Capsule on Hemorheological Parameters in Acute Blood Stasis Animals
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Effects of Guben Yishen Capsule on Hemorheological Parameters in Acute Blood Stasis Animals
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 10, Pages: 169-172(2011)
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Published:2011
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MA Jun, FU Yu, QING Hui-long, et al. Effects of Guben Yishen Capsule on Hemorheological Parameters in Acute Blood Stasis Animals[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(10): 169-172.
DOI:
MA Jun, FU Yu, QING Hui-long, et al. Effects of Guben Yishen Capsule on Hemorheological Parameters in Acute Blood Stasis Animals[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(10): 169-172.DOI:
Effects of Guben Yishen Capsule on Hemorheological Parameters in Acute Blood Stasis Animals
Objective: To explore the effect of Guben Yishen Capsule(GB-C)on the hemorheological parameters for acute blood stasis in rats and mice. Method: The model of blood stasis in rats was prepared by injection of 0.1% epinephrine and putting them into ice-water for several minutes. The model of stasis in mice was established in the similar manner. The whole blood viscosities at low
middleand high shear rates
plasma viscosity
serum viscosity
fibrinogen viscosity
whole blood reduction viscosity
hematocrit
platelet aggregation resistance index and the clotting-time of mice were measured. Result: GB-C at 2.25
0.75 g ·kg-1 doses could markedly decrease the whole blood viscosities at low
middle and high shear rates
plasma viscosity
fibrinogen viscosity
and whole blood reduction viscosities at low
high shear rates and hematocrit were decreased
decrease platelet aggregation resistance index
and the clotting-time of mice was extended(P<0.05
P<0.01). Conclusion: GB-C can ameliorate the indexes in hemorheology in animals with acute blood stasis.
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