Effect of Complex Bajitian Mixture on Expression of Vascular Endothelial Growth Factor in Rat with Steroid-induced Osteonecrosis of Femoral Head
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Effect of Complex Bajitian Mixture on Expression of Vascular Endothelial Growth Factor in Rat with Steroid-induced Osteonecrosis of Femoral Head
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 7, Pages: 117-120(2011)
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Published:2011
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SUN Ke-min, WANG He-ming, LIN Jiu-mao. Effect of Complex Bajitian Mixture on Expression of Vascular Endothelial Growth Factor in Rat with Steroid-induced Osteonecrosis of Femoral Head[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(7): 117-120.
DOI:
SUN Ke-min, WANG He-ming, LIN Jiu-mao. Effect of Complex Bajitian Mixture on Expression of Vascular Endothelial Growth Factor in Rat with Steroid-induced Osteonecrosis of Femoral Head[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(7): 117-120.DOI:
Effect of Complex Bajitian Mixture on Expression of Vascular Endothelial Growth Factor in Rat with Steroid-induced Osteonecrosis of Femoral Head
Objective: To investigate the effect of Complex Bajitian mixture on the expression of VEGF mRNA in SD rats with steroid-induced osteonecrosis of the femoral head. Method: Seventy-two adult SD rats were randomized into four groups: normal control group
model group
positive control group and therapeutic group. Rat model of osteonecrosis of femoral head was established by injecting glucocorticoid. Each group was given drugs by gastric infusion one time a day. The rats were killed in the fourth
eighth and twelfth week respectively. The expression of VEGF mRNA was evaluated by RT-PCR. Result: The expression of VEGF mRNA was increased significantly after treatment on the 12th week compared to the 4th and 8th week (P<0.01). Conclusion: Complex Bajitian mixture can up-regulate the expression of VEGF mRNA. The therapeutic effect is close with the Xianling Gubao capsule.