Toxicity on Fertility and Early Embryo Development by Intragastrical Administration of Cinnabaris in Rat
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Toxicity on Fertility and Early Embryo Development by Intragastrical Administration of Cinnabaris in Rat
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 9, Pages: 226-231(2011)
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Published:2011
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GU Ying-min, LI Yong-mei, JIANG Xin, et al. Toxicity on Fertility and Early Embryo Development by Intragastrical Administration of Cinnabaris in Rat[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(9): 226-231.
DOI:
GU Ying-min, LI Yong-mei, JIANG Xin, et al. Toxicity on Fertility and Early Embryo Development by Intragastrical Administration of Cinnabaris in Rat[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(9): 226-231.DOI:
Toxicity on Fertility and Early Embryo Development by Intragastrical Administration of Cinnabaris in Rat
Objective: To observe the toxicity effect of Cinnabaris on rat fertility and embryo development. Method: Cinnabaris suspension was orally administrated to SD male rats for six weeks and to female rats for two weeks intragastrically before matting at the doses of 1 000
300
100 mg ·kg-1 respectively
until the day males successfully mated and females was pregnant at D6.Male rats were sacrificed after mating
and female rats on D15 of pregnancy. The numbers of corpus luteum
implantation spot
and survival fetus were calculated. Blood cells
biochemistry
urine
and histo-pathological examination and analysis of all rats were carried out to compare with the control group. Result: There were significant differences in mean numbers of survival fetuses and pre-implantation embryo loss in 1 000 mg ·kg-1 group
although no significant differences in pregnant rates were seen. Blood cell and biochemistry examination showed that HGB
HCT
ALT
TP and ALB were significantly decreased as the doses increased in male rats. Pathological lesions were found in testicle
epididymis and seminal vesicle. Conclusion: Cinnabaris has toxicity effect on male rat fertility and early embryo development. Long term administration of Cinnabaris may inhibit erythrocytopoiesis and impair liver function. The functional and pathological changes may attribute to the toxicity of free mercury dissolved in blood.